(±)9-HODE cholesteryl ester (CAS 33783-76-5)

(±)9-HODE cholesteryl ester, identified by the CAS number 33783-76-5, is a cholesteryl ester derivative of the racemic mixture of 9-hydroxyoctadecadienoic acid (9-HODE). This compound is an esterified form of 9-HODE, where the hydroxyl group of 9-HODE is linked to cholesterol, enhancing its lipid solubility and altering its interaction within lipid membranes and lipid domains. In research, (±)9-HODE cholesteryl ester is particularly significant for studying the dynamics of lipid components within cell membranes and their role in modulating cellular signaling pathways. The esterification with cholesterol affects not only the physical properties of cell membranes but also the signaling mechanisms related to lipid rafts and microdomains. This compound has been utilized to explore how modified lipids influence the structural integrity and functionality of membranes, including their effects on receptor localization and signaling efficacy. Researchers have also investigated its role in the formation of oxidized low-density lipoprotein (LDL) particles, which are crucial for understanding lipid peroxidation processes in cellular environments. By examining (±)9-HODE cholesteryl ester, insights are gained into the complex interactions between lipid metabolism and cell signaling, which are essential for elucidating the mechanisms that underlie cellular responses to various physiological and pathophysiological stimuli.