Date published: 2026-6-6

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(±)8-HDoHE (CAS 90780-54-4)

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Application:
(±)8-HDoHE is an autoxidation product of DHA which may serve as a marker for oxidative stress
CAS Number:
90780-54-4
Molecular Weight:
344.5
Molecular Formula:
C22H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)8-HDoHE, catalogued under CAS number 90780-54-4, is a hydroxylated derivative of docosahexaenoic acid (DHA), a crucial omega-3 fatty acid that is abundant in marine sources like fish oil. This specific molecule features a hydroxyl group on the eighth carbon and includes both enantiomers, as indicated by the (±) designation. In the context of scientific research, (±)8-HDoHE is studied for its role as a lipid mediator that can influence various cellular signaling pathways. This compound is particularly interesting due to its potential interaction with enzymes and cellular receptors involved in the regulation of inflammatory and anti-inflammatory processes. By interacting with these molecular pathways, (±)8-HDoHE can affect the production of cytokines, prostaglandins, and leukotrienes, which are critical mediators of cellular responses to stimuli. Studies involving (±)8-HDoHE are directed towards understanding its biochemical properties and its influence on lipid metabolism and signaling pathways. These investigations help to explain the mechanisms through which modifications in the structure of fatty acids can alter their biological activities and interactions with cellular components. Understanding the role of such lipid mediators extends our knowledge of the fundamental processes that govern cellular behavior and response to environmental changes, and it enhances our comprehension of how dietary components can modulate these critical processes.


(±)8-HDoHE (CAS 90780-54-4) References

  1. Stereochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate.  |  Kim, HY., et al. 1990. Prostaglandins. 40: 473-90. PMID: 2147773
  2. Oxidation of docosahexaenoic acid by rat liver microsomes.  |  VanRollins, M., et al. 1984. J Biol Chem. 259: 5776-83. PMID: 6232277
  3. Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate.  |  VanRollins, M. and Murphy, RC. 1984. J Lipid Res. 25: 507-17. PMID: 6234372
  4. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate.  |  Yamane, M., et al. 1994. J Chromatogr. 652: 123-36. PMID: 8006098
  5. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by alpha-tocopherol-directed autoxidation.  |  Reynaud, D., et al. 1993. Anal Biochem. 214: 165-70. PMID: 8250220

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)8-HDoHE, 25 µg

sc-205170
25 µg
$76.00

(±)8-HDoHE, 50 µg

sc-205170A
50 µg
$146.00