Plumbagin CAS: 481-42-5
MF: C11H8O3
MW: 188.18
A potent anticancer agent.

Plumbagin (CAS 481-42-5)

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同义词: 5-Hydroxy-2-methyl-1,4-naphthoquinone
应用; A potent anticancer agent
CAS号码: 481-42-5
分子量: 188.18
分子式: C11H8O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Plumbagin exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma and shows has antifungal, antiviral, and antibacterial action. Plumbagin also suppresses CXCR4 expression, a key component of cancer metastasis studies.


参考文献

Hsu, Y.L., et al., , Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J. Pharmacol. Exp. Ther. 318, 484-494, (2006) Sugie, S., et al., Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 127, 177-183, (1998) Inbaraj, J.J., and Chignell, C.F., Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes. Chem. Res. Toxicol. 17, 55-62, (2004) Jaiswal, A.S., et al., Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1. Oncogene 21, 5912-5922, (2002)

物理状态 :
Solid
来源于 :
Plumbago indica
溶解度 :
Soluble in chloroform (50 mg/ml)
保存 :
Store at -20° C
熔点 :
76-78° C (lit.)
沸点 :
~383.9° C at 760 mmHg (Predicted)
密度 :
~1.4 g/cm3 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
QL8500000
运输 :
UN 2923, Class 8 (6.1), Packing group II
PubChem CID :
10205
SMILES :
CC1=CC(=O)C2=C(C1=O)C=CC=C2O

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引用1 - 33

PMID: # 31227705  2019. Nat Commun. 10: 2745.

PMID: # 28249720  Zhang, J. et al. 2017. Arch. Biochem. Biophys. 619: 16-26.

PMID: # 22669514  Patridge, EV. et al. 2012. Arch. Toxicol. 86: 1613-25.

引用1 - 33
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