plakophilin 3 Antibody (12B11F8): sc-59977
- plakophilin 3 Antibody (12B11F8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 779-793 of plakophilin 3 of human origin
- recommended for detection of plakophilin 3 of mouse, rat, human, Xenopus and canine origin by WB, IP and IF; non cross-reactive with any other plakophilin or armadillo protein
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for plakophilin 3 Antibody (12B11F8) for WB applications. This reagent is now offered in a bundle with plakophilin 3 Antibody (12B11F8) (see ordering information below).
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plakophilin 3 Antibody (12B11F8) is a mouse monoclonal IgG2a antibody that detects plakophilin 3 in mouse, rat, human, Xenopus, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Plakophilin 3 is a 797 amino acid protein that features eight arm-repeats and is a member of the beta-catenin family, playing a crucial role in cellular adhesion and signaling pathways. Plakophilin 3 is primarily localized to desmosomes, which are specialized cell-cell junctions that provide mechanical strength to tissues, particularly in stratified epithelia that experience significant mechanical stress. Plakophilin 3 in desmosomes is vital for maintaining tissue integrity and facilitating communication between cells, which is essential for proper tissue function and response to stress. Notably, plakophilin 3 is encoded by a gene located on human chromosome 11p15.5 and is frequently up-regulated in lung carcinogenesis, suggesting potential as a prognostic marker and therapeutic target in lung cancer. Plakophilin 3′s ability to interact with other proteins involved in desmosome formation and function further underscores its importance in cellular architecture and signaling, making anti-plakophilin 3 antibody (12B11F8) a valuable tool for researchers studying cell adhesion, cancer biology, and tissue development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
plakophilin 3 Antibody (12B11F8) | sc-59977 | 200 µg/ml | $322.00 | |||
plakophilin 3 Antibody (12B11F8): m-IgG Fc BP-HRP Bundle | sc-539155 | 200 µg Ab; 10 µg BP | $361.00 |