plakophilin 3 Antibody (12B11F8): sc-59977

plakophilin 3 Antibody (12B11F8) is a mouse monoclonal IgG2a antibody that detects plakophilin 3 in mouse, rat, human, Xenopus, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Plakophilin 3 is a 797 amino acid protein that features eight arm-repeats and is a member of the beta-catenin family, playing a crucial role in cellular adhesion and signaling pathways. Plakophilin 3 is primarily localized to desmosomes, which are specialized cell-cell junctions that provide mechanical strength to tissues, particularly in stratified epithelia that experience significant mechanical stress. Plakophilin 3 in desmosomes is vital for maintaining tissue integrity and facilitating communication between cells, which is essential for proper tissue function and response to stress. Notably, plakophilin 3 is encoded by a gene located on human chromosome 11p15.5 and is frequently up-regulated in lung carcinogenesis, suggesting potential as a prognostic marker and therapeutic target in lung cancer. Plakophilin 3′s ability to interact with other proteins involved in desmosome formation and function further underscores its importance in cellular architecture and signaling, making anti-plakophilin 3 antibody (12B11F8) a valuable tool for researchers studying cell adhesion, cancer biology, and tissue development.

The preferred plakophilin 3 antibody is plakophilin 3 Antibody (E-10): sc-166655.