PKA Phosphopeptide Substrate Antibody (BDI251): sc-56941

PKA Phosphopeptide Substrate Antibody (BDI251) is a mouse monoclonal IgG1 antibody that detects PKA in non-species reactive samples by enzyme-linked immunosorbent assay (ELISA). PKA, or cAMP-dependent protein kinase, plays a crucial role in cellular signaling pathways by mediating the effects of cyclic AMP, which is vital for regulating various physiological processes such as metabolism, gene expression, and cell proliferation. The structure of PKA consists of a tetrameric holoenzyme formed by two regulatory and two catalytic subunits, which allows for precise control of activity. When cAMP levels rise, binding to the regulatory subunits causes a conformational change that releases the active catalytic subunits, enabling phosphorylation of target proteins. This phosphorylation cascade is essential for the activation of transcription factors like cAMP response element binding protein (CREB), which subsequently influences gene expression. PKA Phosphopeptide Substrate (BDI251) antibody serves as an invaluable tool for researchers studying the intricate signaling mechanisms mediated by PKA and its role in various cellular functions.

The preferred PKA Phosphopeptide Substrate antibody is PKA Phosphopeptide Substrate Antibody (15B12): sc-65491.