Date published: 2025-9-9

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PIPK II α 抗体 (149.1): sc-100406

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说明书
  • PIPK II alpha 抗体 149.1 是小鼠单克隆 IgG1 κ,PIPK II α抗体, 在4篇文献中引用,规格为100 µg/ml
  • 免疫human物种的重组PIPK II α
  • 推荐用于 mouse, rat 和 human 来源的PIPK II α WB, IP, IF, IHC(P) 和 ELISA检测; 可能与 PIPK II β产生交联反应
  • 目前,我们还没有完成PIPK II α 抗体 (149.1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

PIPK II α 抗体(149.1)是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的 PIPK II α 蛋白。抗PIPK II alpha抗体(149.1)以非结合形式提供。PIPK II alpha蛋白在合成磷脂酰肌醇-4,5-二磷酸(一种对细胞增殖、存活、膜转运和细胞骨架组织等多种细胞过程至关重要的脂质)中起着至关重要的作用。PIPK II alpha蛋白主要位于大脑中,有助于调节神经元功能和通信所必需的信号通路。PIPK家族分为三种类型,其中II型PIPK(包括PIPK II α和β)在神经组织中的高表达水平尤为重要。PIPK II α在脑中的存在凸显了其在神经生物学中的重要性,它涉及对学习和记忆至关重要的突触活动和可塑性的调节。通过促进磷脂酰肌醇-4,5-二磷酸的产生,PIPK II alpha成为信号转导通路中的关键信使,使其成为神经退行性疾病和其他影响神经系统疾病研究的重要靶标。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PIPK II α 抗体 (149.1) 参考文献:

  1. 磷脂酰肌醇(PI)-5-磷酸 4-激酶 II 型酶通过调节 PI-3,4,5- 三磷酸降解来控制胰岛素信号传导。  |  Carricaburu, V., et al. 2003. Proc Natl Acad Sci U S A. 100: 9867-72. PMID: 12897244
  2. 人磷脂酰肌醇-3-磷酸 5-激酶 PIKfyve/Fab1 的克隆和亚细胞定域。  |  Cabezas, A., et al. 2006. Gene. 371: 34-41. PMID: 16448788
  3. 哺乳动物的磷脂酰肌醇-3-磷酸 5-激酶(PIKfyve)调控内膜到 TGN 的逆向运输。  |  Rutherford, AC., et al. 2006. J Cell Sci. 119: 3944-57. PMID: 16954148
  4. II 型 PtdInsP 激酶:位置, 调节和功能。  |  Clarke, JH., et al. 2007. Biochem Soc Symp. 149-59. PMID: 17233588
  5. 使脂类和多糖磷酸化的酶。  |  Karataeva, NA. and Nevinsky, GA. 2007. Biochemistry (Mosc). 72: 367-79. PMID: 17511601
  6. 产生多功能信号磷脂 PI4,5P(2)的磷脂激酶 PIP5K。  |  Kanaho, Y., et al. 2007. Biol Pharm Bull. 30: 1605-9. PMID: 17827707
  7. 磷脂酰肌醇-4-磷酸 5-激酶可降低培养的集合管细胞上皮钠通道(ENaC)的细胞表面表达。  |  Weixel, KM., et al. 2007. J Biol Chem. 282: 36534-42. PMID: 17940289
  8. 细胞信号级联中的 II 型磷脂酰肌醇 4- 激酶。  |  Sinha, RK. and Subrahmanyam, G. 2007. Indian J Biochem Biophys. 44: 289-94. PMID: 18341203
  9. beta-restin 对磷脂酰肌醇-4-磷酸 5-激酶 Ialpha 的支架作用可促进激动剂刺激下的β2-肾上腺素能受体封闭。  |  Nelson, CD., et al. 2008. J Biol Chem. 283: 21093-101. PMID: 18534983
  10. PIP4K2A通过调节PI(4,5)P2的稳态来调节细胞内胆固醇的运输。  |  Hu, A., et al. 2018. J Lipid Res. 59: 507-514. PMID: 29353240
  11. PIKFYVE依赖性癌细胞与非恶性细胞的区别在于PIP5K1C磷脂酰肌醇激酶的缺乏。  |  Roy, A., et al. 2023. Autophagy. 19: 2464-2484. PMID: 36803256
  12. 通过多组学分析探索与阿尔茨海默病相关的少突胶质细胞PIP4K2A在伴有2型糖尿病的阿尔茨海默病中的潜在作用。  |  Nguyen, DPQ., et al. 2024. Int J Mol Sci. 25: PMID: 38928345

订购信息

产品名称产品编号规格价格数量收藏夹

PIPK II α 抗体 (149.1)

sc-100406
100 µg/ml
$333.00

Can sc-100406: PIPK II α (149.1) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, sc-100406: PIPK II α (149.1) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Great dataThis antibody will provide you with the desired results in staining and blotting. Staining is clear and specific and blotting has strong bands at the expected weight. This antibody has been used to publish.
Date published: 2017-02-08
Rated 5 out of 5 by from Performs well in WesternPerforms well in Western, good signal with mouse PIPK II transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-05-25
Rated 5 out of 5 by from Exceptional immunoperoxidase nuclear stainingExceptional immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human small Intestine tissue. -SCBT QC
Date published: 2015-03-26
Rated 5 out of 5 by from Great antibody for WBGreat antibody for WB, works in K-562 whole cell lysate. -SCBT QC
Date published: 2015-03-16
Rated 5 out of 5 by from Band detected at expected mw in HeLa wholeBand detected at expected mw in HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-04
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PIPK II α 抗体 (149.1) is rated 5.0 out of 5 by 5.
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