Date published: 2025-9-8

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PIPK I γ 抗体 (D-7): sc-377330

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说明书
  • PIPK I γ抗体(D-7)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 与氨基酸序列C-terminus(h)对应的多肽序列(PIPK I γ的mouse起源)
  • 推荐用于 mouse 和 rat 来源的PIPK I γ WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP是PIPK I γ Antibody (D-7) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与PIPK I γ Antibody (D-7) 搭配使用(请参阅下面的订购信息)。

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    関連項目

    磷脂酰肌醇-4-磷酸-5-激酶(PIPK)合成磷脂酰肌醇-4,5-二磷酸,该物质可调节包括细胞增殖、存活、膜转运和细胞骨架组织在内的各种过程。PIPK家族分为I型、II型和III型。PIPK家族的每种类型都磷酸化不同的底物,并且它们含有一个激活环,这决定了它们的酶特异性和亚细胞定位。磷脂酰肌醇-4-磷酸-5-激酶I型由三个成员组成,即PIPK I α、β和γ,它们的特点是在5-羟基上磷酸化PI4P。PIPK I α(在小鼠中称为PIPK I β)在脑组织中表达。PIPK I β(在小鼠中称为PIPK I a)也被称为STM7。PIPK I γ通过选择性剪接产生两种变体,在肺、脑和肾脏中表达。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PIPK I γ 抗体 (D-7) 参考文献:

    1. 磷酸化调节的Igamma型磷脂酰肌醇磷酸激酶(PIPKIgamma)靶向聚焦粘附的结构基础。  |  Kong, X., et al. 2006. J Mol Biol. 359: 47-54. PMID: 16616931
    2. PIPKIγ调节生长因子受体信号下游的β-catenin转录活性。  |  Schramp, M., et al. 2011. Cancer Res. 71: 1282-91. PMID: 21303971
    3. PIPKIγ 调节结肠癌细胞的粘附斑动力学和侵袭性。  |  Wu, Z., et al. 2011. PLoS One. 6: e24775. PMID: 21931851
    4. PIPKIγ 以中心体为靶点,抑制中心粒复制。  |  Xu, Q., et al. 2014. J Cell Sci. 127: 1293-305. PMID: 24434581
    5. PIPKIγ的异构体5调节E-cadherin的内吞体运输和降解。  |  Schill, NJ., et al. 2014. J Cell Sci. 127: 2189-203. PMID: 24610942
    6. FAK, talin 和 PIPKIγ 可调节内吞整合素的活化,从而极化 focal adhesion 组装。  |  Nader, GP., et al. 2016. Nat Cell Biol. 18: 491-503. PMID: 27043085
    7. 磷脂酰肌醇磷酸激酶 PIPKIγ 和磷酸化酶 INPP5E 协调纤毛生成的启动。磷脂酰肌醇磷酸激酶 PIPKIγ 和 Talin 将磷脂酰肌醇和粘附信号结合起来,控制上皮细胞向间质细胞的转变。  |  Thapa, N., et al. 2017. Oncogene. 36: 899-911. PMID: 27452517
    8. Smurf1 通过与 PIPKIγ 的相互作用和泛素化调节肺癌细胞的生长和迁移。  |  Li, H., et al. 2017. Oncogene. 36: 5668-5680. PMID: 28581524
    9. PIPKIγ 通过激活AKT-STAT3信号传导来调节结肠癌中的CCL2表达。  |  Xue, J., et al. 2019. J Immunol Res. 2019: 3690561. PMID: 31781676
    10. 纤毛病蛋白 HYLS1 通过激活纤毛脂质激酶 PIPKIγ 来协调初级纤毛的生物发生和信号传导。  |  Chen, C., et al. 2021. Sci Adv. 7: PMID: 34162535

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PIPK I γ 抗体 (D-7)

    sc-377330
    200 µg/ml
    $316.00

    PIPK I γ (D-7): m-IgG Fc BP-HRP 套装

    sc-540709
    200 µg Ab; 10 µg BP
    $354.00

    PIPK I γ (D-7) 中和勝肽

    sc-377330 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-377330 P appropriate for?

    Asked by: Germaine
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Produced exceptional immunofluorescence cytoplasmicProduced exceptional immunofluorescence cytoplasmic staining in methanol-fixed NIH/3T3 cells. -SCBT QC
    Date published: 2015-03-14
    Rated 5 out of 5 by from Nice Western Blot data of PIPK I expressionNice Western Blot data of PIPK I expression in mouse brain tissue extract. -SCBT QC
    Date published: 2014-01-23
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    PIPK I γ 抗体 (D-7) is rated 5.0 out of 5 by 2.
    • y_2025, m_8, d_27, h_5
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