PHT-427 (CAS 1191951-57-1)
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PHT-427 is a dual Akt and PKB Kinase (PDPK1) inhibitor (Ki values: Akt = 2.7 μM and PKB Kinase (PDPK1) = 5.2 μM). PHT-427 is a pleckstrin homology domain inhibitor to Akt/PKB Kinase (PDPK1). PHT-427 significantly reduces phosphorylation of phospho-Ser241-PKB Kinase (PDPK1) and phospho-Thr308-Akt in PC-3 prostate cancer cells which shows that PHT-427 could inhibit both Akt and PKB Kinase (PDPK1). PHT-427 also inhibits translocation of the Akt and PKB Kinase (PDPK1) PH domains in plasma membrane. PHT-427 induces apoptosis and inhibits Akt phosphorylation (IC50 = 6.3 μM), mainly on Akt Ser473 residue and less strongly on the Akt Thr308 residue without affecting total Akt protein expression. PHT-427 also shows antiproliferation in Panc-1 cells (IC50 = 65 μM).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHT-427, 10 mg | sc-364582 | 10 mg | $68.00 | |||
PHT-427, 50 mg | sc-364582A | 50 mg | $405.00 |