Molecular structure of Pheophorbide a, CAS Number: 15664-29-6
Pheophorbide a (CAS 15664-29-6)
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Alternate Names:
Pheophorbide a is also known as 3-[(3S,4S,21R)-14-Ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinyl-3-phorbinyl]propanoic acid.
Application:
Pheophorbide a is a chlorophyll-related compound studied for its anti-tumor and anti-cancer activity.
CAS Number:
15664-29-6
Purity:
≥90%
Molecular Weight:
592.69
Molecular Formula:
C35H36N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pheophorbide a is a chlorophyll derivative that has gained interest in the field of photodynamic research. As a result of its photophysical properties, it is frequently used in studies investigating the mechanisms of light-absorption and energy transfer in photosynthetic organisms. Pheophorbide a is also a key compound in research on photodynamic processes, where it acts as a photosensitizer due to its ability to generate reactive oxygen species upon light excitation. This makes it useful for understanding the effects of photo-induced oxidative stress in biological systems. Moreover, Pheophorbide a is used in the examination of the degradation pathways of chlorophyll in plants, providing insights into how chlorophyll is broken down into different metabolites during processes such as leaf senescence or fruit ripening.
Pheophorbide a (CAS 15664-29-6) References
- Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells. | Chan, JY., et al. 2006. Planta Med. 72: 28-33. PMID: 16450292
- Derivatives of pheophorbide-a and pheophorbide-b from photocytotoxic Piper penangense extract. | Kamarulzaman, FA., et al. 2011. Chem Biodivers. 8: 494-502. PMID: 21404433
- The chlorophyll catabolite pheophorbide a as a photosensitizer for the photodynamic therapy. | Xodo, LE., et al. 2012. Curr Med Chem. 19: 799-807. PMID: 22214455
- Pheophorbide a from Capsosiphon fulvescens Inhibits Advanced Glycation End Products Mediated Endothelial Dysfunction. | Hong, CO., et al. 2016. Planta Med. 82: 46-57. PMID: 26308358
- Seasonal variation of pheophorbide a and flavonoid in different organs of two Carpinus species and its correlation with immunosuppressive activity. | Sheng, Q., et al. 2016. In Vitro Cell Dev Biol Anim. 52: 654-61. PMID: 27112162
- Pheophorbide a, a compound isolated from the leaves of Arrabidaea chica, induces photodynamic inactivation of Trypanosoma cruzi. | Miranda, N., et al. 2017. Photodiagnosis Photodyn Ther. 19: 256-265. PMID: 28587855
- Oxime-based 19-nortestosterone-pheophorbide a conjugate: bimodal controlled release concept for PDT. | Pavlíčková, V., et al. 2019. J Mater Chem B. 7: 5465-5477. PMID: 31414695
- Identification of pheophorbide a as an inhibitor of receptor for advanced glycation end products in Mallotus japonicus. | Matsumoto, T., et al. 2021. J Nat Med. 75: 675-681. PMID: 33625682
- Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts. | Lee, H., et al. 2021. Life (Basel). 11: PMID: 33671886
- Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. | Kim, J., et al. 2022. Biomed Pharmacother. 147: 112664. PMID: 35131655
- Pheophorbide A and SN38 conjugated hyaluronan nanoparticles for photodynamic- and cascadic chemotherapy of cancer stem-like ovarian cancer. | Lee, J., et al. 2022. Carbohydr Polym. 289: 119455. PMID: 35483857
- Anti-adipogenic activities of pheophorbide a and pyropheophorbide a isolated from wild bitter gourd (Momordica charantia L. var. abbreviata Seringe) in vitro. | Liu, YH., et al. 2022. J Sci Food Agric. 102: 6771-6779. PMID: 35638177
- Pheophorbide A isolated from Gelidium amansii inhibits adipogenesis by regulating adipogenic transcription factors and AMPK in 3T3-L1 adipocytes. | Park, MH., et al. 2022. Nutr Res. 107: 187-194. PMID: 36323192
- Pheophorbide A-Mediated Photodynamic Therapy Potentiates Checkpoint Blockade Therapy of Tumor with Low PD-L1 Expression. | Tong, Q., et al. 2022. Pharmaceutics. 14: PMID: 36432703
- Pheophorbide-a as a Light-Triggered Liposomal Switch: For the Controlled Release of Alpinia galanga (A. galanga) Essential Oil and Its Stability, Antioxidant, and Antibacterial Activity Assessment. | Ge, X., et al. 2023. J Agric Food Chem. 71: 1667-1678. PMID: 36629793
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RNase III Drosha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pheophorbide a, 10 mg | sc-264070B | 10 mg | $70.00 | |||
Pheophorbide a, 50 mg | sc-264070 | 50 mg | $281.00 | |||
Pheophorbide a, 100 mg | sc-264070A | 100 mg | $459.00 | |||
Pheophorbide a, 250 mg | sc-264070C | 250 mg | $1121.00 | |||
Pheophorbide a, 1 g | sc-264070F | 1 g | $2039.00 | |||
Pheophorbide a, 5 g | sc-264070D | 5 g | $7445.00 | |||
Pheophorbide a, 10 g | sc-264070E | 10 g | $13525.00 |