PHA-793887 CAS: 718630-59-2
MF: C19H31N5O2
MW: 361.48
A novel pan-Cdk inhibitor inactive against 34 other kinases.

PHA-793887 (CAS 718630-59-2)

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应用; PHA-793887 is a novel pan-Cdk inhibitor inactive against 34 other kinases
CAS号码: 718630-59-2
分子量: 361.48
分子式: C19H31N5O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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PHA-793887 is a novel pan-Cdk inhibitor, including Cdk1, Cdk2, Cdk4, Cdk5, Cdk7, and Cdk9 with IC50's in the 5 to 140 nM range. PHA-793887 is inactive against 34 other kinases representative of all kinase families, in particular c-abl, c-kit, lck, and TRKA with IC50>10 mM. PHA-793887 shows anti-proliferative activity against several solid tumor cell lines, with IC50<1 mM; in these cells, it is able to inhibit Rb phosphorylation and expression of S-phase cyclins, such as cyclin A.

物理状态 :
Solid
保存 :
Store at -20° C
熔点 :
>147° C (dec.)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C

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