Date published: 2025-9-9

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PGAM1/4 抗体 (C-5): sc-376638

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说明书
  • PGAM1/4抗体(C-5)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 针对PGAM1的human起源的内部区域内的肽图
  • 推荐用于 PGAM1 of mouse, rat and human origin, and PGAM4 of human origin WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是PGAM1/4 Antibody (C-5) for WB applications. 的首选辅助检测试剂,这些试剂现与PGAM1/4 Antibody (C-5) 打包提供(请参阅下面的订购信息)。

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関連項目

磷酸甘油酸变位酶(PGAM)家族的蛋白质是葡萄糖和2,3-BPGA(2,3-二磷酸甘油酸)代谢的重要组成部分。它们负责催化磷酸基团在磷酸甘油酸的碳原子之间的转移。在哺乳动物中,存在两种类型的PGAM同工酶:PGAM1(也称为PGAMB)和PGAM2(也称为PGAMA)。在细胞中,PGAM1和PGAM2以同二聚体或异二聚体的形式存在,并负责3-磷酸甘油酸和2-磷酸甘油酸的相互转化。PGAM2同二聚体在骨骼肌、成熟精子和心脏中表达;PGAM1同二聚体存在于大多数其他组织中;而PGAM1/PGAM2异二聚体仅在心脏中发现。PGAM4,也称为PGAM3,是一种以前被认为是人类特有的蛋白质。最初,PGAM4基因被描述为假基因,但现在已知它编码一种至少有2500万年历史的功能性蛋白质。编码PGAM4的基因被认为是通过反转录转座产生的,其原始拷贝是PGAM1基因。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PGAM1/4 抗体 (C-5) 参考文献:

  1. PGAM1基因敲除与丁螺环酮诱导的精子生成减少和生精细胞凋亡有关。  |  Zhao, Y. and Zhang, S. 2019. Mol Med Rep. 19: 2497-2502. PMID: 30720109
  2. 一种异构 PGAM1 抑制剂能有效抑制胰腺导管腺癌。  |  Wen, CL., et al. 2019. Proc Natl Acad Sci U S A. 116: 23264-23273. PMID: 31662475
  3. PGAM1 缺乏症可通过抑制炎症、细胞凋亡和纤维化,以 TGF-β 为靶点,改善心肌梗死的重塑。  |  Wu, Y., et al. 2021. Biochem Biophys Res Commun. 534: 933-940. PMID: 33168191
  4. PGAM1 对 ASS1 的调控通过 cAMP/AMPK/CEBPB 通路促进了乳腺癌的进展。  |  Liu, M., et al. 2022. Mol Oncol. 16: 2843-2860. PMID: 35674458
  5. PGAM1 通过产生丙酮酸促进卵巢癌细胞的糖酵解代谢和紫杉醇抗性  |  Feng, Y., et al. 2022. Front Biosci (Landmark Ed). 27: 262. PMID: 36224008
  6. 由 SMC4 衰减诱导的二尖瓣样结直肠癌细胞具有低增殖和对化疗不敏感的特点。  |  Sun, X., et al. 2023. Cell Metab. 35: 1563-1579.e8. PMID: 37543034
  7. RFX6 通过靶向 PGAM1 促进有氧糖酵解介导的肝细胞癌生长和转移。  |  Qiu, Z., et al. 2023. Clin Transl Med. 13: e1511. PMID: 38093528
  8. PGAM1 的泛癌分析及其在葡萄膜黑色素瘤进展中的实验验证  |  Niu, W., et al. 2024. J Cancer. 15: 2074-2094. PMID: 38434965
  9. 抑制 PGAM1 可重塑三阴性乳腺癌的肿瘤微环境,并与抗 PD-1 免疫疗法协同作用。  |  Zhang, D., et al. 2024. J Leukoc Biol. 116: 579-588. PMID: 38478709
  10. PKM2 作为组氨酸激酶,可使 PGAM1 磷酸化并增加癌症中的糖酵解分流。  |  Wang, Y., et al. 2024. EMBO J. 43: 2368-2396. PMID: 38750259

订购信息

产品名称产品编号规格价格数量收藏夹

PGAM1/4 抗体 (C-5)

sc-376638
200 µg/ml
$316.00

PGAM1/4 (C-5): m-IgG Fc BP-HRP 套装

sc-540619
200 µg Ab; 10 µg BP
$354.00

PGAM1/4 (C-5): m-IgG1 BP-HRP 套装

sc-542250
200 µg Ab; 20 µg BP
$354.00

What is the recommended starting dilution for Western blot for PGAM1/4 (C-5): sc-376638 monoclonal antibody?

Asked by: Dr Ninau Qelp
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-376638.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by from Nice Western Blot data of PGAM1 expression in nonNice Western Blot data of PGAM1 expression in non-transfected and mouse PGAM1 transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-02-10
Rated 5 out of 5 by from Nice Western Blot data of PGAM1 expression in nonNice Western Blot data of PGAM1 expression in non-transfected and human PGAM1 transfected 293T whole cell lysates and HeLa nuclear extract . -SCBT QC
Date published: 2013-12-26
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PGAM1/4 抗体 (C-5) is rated 5.0 out of 5 by 2.
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