Perillic Acid CAS: 23635-14-5
MF: C10H14O2
MW: 166.22
An apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells.

Perillic Acid (CAS 23635-14-5)

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同义词: (S)-4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic acid
应用; An apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells
CAS号码: 23635-14-5
纯度: 95%
分子量: 166.22
分子式: C10H14O2
* 参考分析证明 大量特定数据 (包括水 含量).
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Perillic Acid, a metabolite of perillyl alcohol, has been shown to elicit cytotoxicity, induce cell cycle arrest and apoptosis via an increase in expression of p21, Bax, and caspase-3 activity in cells. This compound has also been found to be a major metabolite of d-limonene (sc-205283), a solvent of cholesterol. Perillic Acid has been noted to inhibit isoprenylation. Studies suggest that this agent has demonstrated the capacity to produce morphological changes to murine lens epithelial cells in culture and cause opacification of the lenses.


参考文献

1. Cheng, Q.F., et al. 2001. Exp. Eye Res. 73: 239-245. PMID: 11446774
2. Chow, H.H., et al. 2002. Cancer Epidemiol. Biomarkers Prev. 11: 1472-1476. PMID: 12433729
3. Yeruva, L., et al. 2007. Cancer Lett. 257: 216-226. PMID: 17888568

物理状态 :
Solid
溶解度 :
Soluble in DMSO, and ethanol.
保存 :
Store at 4° C
熔点 :
129-131° C (lit.)
沸点 :
284.94° C at 760 mmHg
密度 :
1.07 g/cm3
折射率 :
n20D 1.51
光学活性 :
α20/D -102°, c = 2 in methanol
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
2724160
MDL 号码 :
MFCD00062539
EC号码 :
231-709-5
SMILES :
CC(=C)[[email protected]]1CCC(=CC1)C(=O)O

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