Date published: 2025-9-7
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Per2 Antibody (19-J6) - Immunohistochemistry - Image 36294
Per2 抗体 (19-J6): sc-101105. 福尔马林固定, 石蜡包埋的人食管组织的免疫过氧化物酶染色, 显示核定位.
Per2 Antibody (19-J6) - Immunohistochemistry - Image 36294
Per2 抗体 (19-J6): sc-101105. 福尔马林固定, 石蜡包埋的人食管组织的免疫过氧化物酶染色, 显示核定位.
Per2 Antibody (19-J6) - Western Blotting - Image 109338
Per2 抗体 (19-J6): sc-101105. 非转染: sc-117752 (A) 和人 Per2 转染: sc-129449 (B) 293T 全细胞裂解液中 Per2 表达的 Western 印迹分析.
Per2 抗体 (19-J6): sc-101105. 福尔马林固定, 石蜡包埋的人食管组织的免疫过氧化物酶染色, 显示核定位.

Per2 抗体 (19-J6): sc-101105

3.8(4)
寫評論提問

说明书
  • Per2抗体(19-J6)是小鼠单克隆IgG2b κ, 在7篇文献中引用，规格为50 µg/0.5 ml
  • 免疫human物种的重组Per2
  • 推荐用于 human 来源的Per2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前，我们还没有完成Per2 抗体 (19-J6)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Per 抗体 包括 Per1, Per2和Per3

生物计时器，即昼夜节律钟，负责调节激素节律、睡眠周期和其他行为。位于大脑的超交叉核（SCN）是第一个被发现的哺乳动物昼夜节律钟。已经确定了许多似乎是SCN钟的分子成分的转录因子。Clock基因内的突变增加了内源性周期的长度，并导致昼夜节律振荡的节律性丧失。三种哺乳动物周期蛋白，称为Per1、Per2和Per3，在SCN中表现出昼夜节律。在主观夜间，Per1和Per2的RNA水平会增加以应答光脉冲，而Per3的RNA水平则不会因光脉冲而改变。Tim（代表无时间）与Per1以及Per2相互作用；Tim和Per1负调节Clock-BMAL1诱导的转录。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Per2 抗体 (19-J6) 参考文献:

  1. PER-2 的生化特征和 blaPER-2 的遗传环境。  |  Power, P., et al. 2007. Antimicrob Agents Chemother. 51: 2359-65. PMID: 17438050
  2. SIRT1 通过 PER2 去乙酰化调节昼夜节律钟基因的表达。  |  Asher, G., et al. 2008. Cell. 134: 317-28. PMID: 18662546
  3. NAD+ 通过 PER2 核易位控制昼夜节律重编程以对抗衰老  |  Levine, DC., et al. 2020. Mol Cell. 78: 835-849.e7. PMID: 32369735
  4. PER1是卵巢癌的预后生物标志物，与免疫浸润相关。  |  Katoku-Kikyo, N., et al. 2021. J Cell Biol. 220: PMID: 34009269
  5. PER2通过PPARγ/AKT1/β-catenin轴介导成骨细胞分化  |  Huang, W., et al. 2021. Int J Oral Sci. 13: 16. PMID: 34011974
  6. PERIOD 2通过PER2/pGSK3β/β-catenin/Per2环路调节低剂量辐射防护。  |  Alexandrou, AT., et al. 2022. iScience. 25: 105546. PMID: 36465103
  7. PER2 整合了昼夜节律紊乱和垂体肿瘤发生。  |  Guo, L., et al. 2023. Theranostics. 13: 2657-2672. PMID: 37215573
  8. 通过抑制 IKK/NF-κB 通路和 PD-L1 的表达，PER2 与 HSP90 结合可增强针对口腔鳞状细胞癌的免疫反应。  |  Zhang, Z., et al. 2023. J Immunother Cancer. 11: PMID: 37914384
  9. Per2 在应激过程中保护心脏线粒体的重要性  |  Bhaskara, M., et al. 2024. Sci Rep. 14: 1290. PMID: 38221535
  10. 揭示头孢羟氨苄对产生 PER-2 的肠杆菌的活性。  |  Ruggiero, M., et al. 2024. Antimicrob Agents Chemother. 68: e0172023. PMID: 38690895

订购信息

产品名称产品编号规格价格数量收藏夹

Per2 抗体 (19-J6)

sc-101105
50 µg/0.5 ml
$333.00

Can sc-101105: Per2 (19-J6) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jenniferc
Thank you for your question. Yes, sc-101105: Per2 (19-J6) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from positive specificity for western blotWe used this antibody for Per2 expression detection with western blot. We got a positive band at the correct molecular weight
Date published: 2017-02-02
Rated 3 out of 5 by from Positive results in western blot using humanPositive results in western blot using human Per2 transfected whole cell lysates. -SCBT QC
Date published: 2015-04-03
Rated 3 out of 5 by from Acceptable immunoperoxidase nuclear stainingAcceptable immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human esophagus tissue. -SCBT QC
Date published: 2015-02-14
Rated 4 out of 5 by from Published immunohistochemical analysis ofPublished immunohistochemical analysis of human liver biopsies. -SCBT Publication Review
Date published: 2015-01-10
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Per2 抗体 (19-J6) is rated 3.8 out of 5 by 4.
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