Date published: 2025-9-7

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PDCD1LG2/PD-L2 抗体 (TY25): sc-57398

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说明书
  • PDCD1LG2/PD-L2 抗体 TY25 是大鼠单克隆 IgG2aPDCD1LG2/PD-L2抗体, 在1篇文献中引用,规格为200 µg/ml
  • 针对PD-L2 mouse来源的RAW264.7细胞
  • PDCD1LG2/PD-L2 抗体 (TY25) 推荐用于WB, IP, IF, IHC(P) 和 FCM,检测mouse 来源的 PD-L2
  • 抗PDCD1LG2/PD-L2抗体(TY25)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取PDCD1LG2/PD-L2 (TY25): sc-57398免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成PDCD1LG2/PD-L2 抗体 (TY25)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Pdcd-1L2 抗体 (TY25) 是一种大鼠单克隆 IgG2a 抗体,可通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF)、石蜡包埋切片免疫组织化学 (IHCP) 和流式细胞术 (FCM) 检测小鼠来源的 Pdcd-1L2 蛋白。抗 Pdcd-1L2 抗体 (TY25) 有非共轭型和多种共轭型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。Pdcd-1L2 又称程序性细胞死亡配体-2,是一种 73 个氨基酸的 I 型跨膜蛋白,在免疫系统中发挥着至关重要的作用,它向 T 细胞提供抑制信号,从而调节免疫反应并维持耐受性。Pdcd-1L2 的结构包括信号序列、免疫球蛋白 V 样结构域和 C 样结构域、跨膜区和胞质区,它们对于介导与免疫受体的相互作用至关重要。编码 Pdcd-1L2 的基因位于人类染色体 9p24.2,Pdcd-1L2 在心脏、肺部和肾脏等多种实质细胞上的表达表明,Pdcd-1-Pdcd-L 系统可能在通过调节 T 细胞活性预防自身免疫性疾病方面起着关键作用。Pdcd-1L2 与免疫系统中其他蛋白质相互作用的能力进一步强调了它在维持免疫平衡和防止过度免疫反应方面的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PDCD1LG2/PD-L2 抗体 (TY25) 参考文献:

  1. B7-H1 是 B7 家族的第三个成员,可共同刺激 T 细胞增殖和白细胞介素-10 的分泌。  |  Dong, H., et al. 1999. Nat Med. 5: 1365-9. PMID: 10581077
  2. 新型 B7 家族成员与 PD-1 免疫抑制受体的接合导致对淋巴细胞活化的负向调节。  |  Freeman, GJ., et al. 2000. J Exp Med. 192: 1027-34. PMID: 11015443
  3. PD-L2 是 PD-1 的第二配体,可抑制 T 细胞的活化。  |  Latchman, Y., et al. 2001. Nat Immunol. 2: 261-8. PMID: 11224527
  4. PD-1:一种参与外周耐受的抑制性免疫受体。  |  Nishimura, H. and Honjo, T. 2001. Trends Immunol. 22: 265-8. PMID: 11323285

订购信息

产品名称产品编号规格价格数量收藏夹

PDCD1LG2/PD-L2 抗体 (TY25)

sc-57398
200 µg/ml
$316.00

PDCD1LG2/PD-L2 抗体 (TY25) AC

sc-57398 AC
500 µg/ml, 25% agarose
$416.00

PDCD1LG2/PD-L2 抗体 (TY25) HRP

sc-57398 HRP
200 µg/ml
$316.00

PDCD1LG2/PD-L2 抗体 (TY25) FITC

sc-57398 FITC
200 µg/ml
$330.00

PDCD1LG2/PD-L2 抗体 (TY25) PE

sc-57398 PE
200 µg/ml
$343.00

PDCD1LG2/PD-L2 抗体 (TY25) Alexa Fluor® 488

sc-57398 AF488
200 µg/ml
$357.00

PDCD1LG2/PD-L2 抗体 (TY25) Alexa Fluor® 546

sc-57398 AF546
200 µg/ml
$357.00

PDCD1LG2/PD-L2 抗体 (TY25) Alexa Fluor® 594

sc-57398 AF594
200 µg/ml
$357.00

PDCD1LG2/PD-L2 抗体 (TY25) Alexa Fluor® 647

sc-57398 AF647
200 µg/ml
$357.00

PDCD1LG2/PD-L2 抗体 (TY25) Alexa Fluor® 680

sc-57398 AF680
200 µg/ml
$357.00

PDCD1LG2/PD-L2 抗体 (TY25) Alexa Fluor® 790

sc-57398 AF790
200 µg/ml
$357.00

Can this antibody be applied to human-derived cells?

Asked by: Tarotaro
Thank you for your question. Pdcd-1L2 Antibody (TY25): sc-57398 is only recommended for detection of Pdcd-1L2 of murine origin by WB, IP, IF, IHC(P) and FCM. It is not suitable for human cells. We also offer Pdcd-1L2 Antibody (XX19): sc-80285, which is recommended for detection of Pdcd-1L2 of human origin by WB, IF and IHC(P).
Answered by: Tech Support Europe
Date published: 2020-07-29

Are there any issues with using sc-57398: Pdcd-1L2 (TY25) mouse monoclonal primary antibody on mouse samples?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-57398 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Good for Western BlotThis antibody has been used to detect Pdcd-1L2 by Western Blot in published research. -SCBT QC
Date published: 2023-09-14
Rated 3 out of 5 by from Does not cross-react against canine PD-L2This mAb does not cross-react against canine PD-L2 for WB, but sc-57398 is only recommended for detection of Pdcd-1L2 of murine origin so it's nothing special. I describe this for those who try to use like me just in case.
Date published: 2021-07-06
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PDCD1LG2/PD-L2 抗体 (TY25) is rated 3.3 out of 5 by 3.
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