PD 166285 CAS: 212391-63-4
MF: C26H27Cl2N5O2•2HCl
MW: 585.35
An inhibitor of RTK, c-Src, FGFR1, Wee 1, and PDGFRβ.

PD 166285 (CAS 212391-63-4)

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备用名: Heparin-Cantithrombin II
应用; PD 166285 is an inhibitor of RTK, c-Src, FGFR1, Wee 1, and PDGFRβ
CAS号码: 212391-63-4
纯度: ≥98%
分子量: 585.35
分子式: C26H27Cl2N5O22HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

PD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. PD 166285 is an RTK inhibitor with broad-spectrum properties and displays anti-angiogenic activity and anti-tumor efficacy when used with PDT (photodynamic therapy). PD 166285 is an inhibitor of EGFR.


参考文献

Star, W., et al.: Cancer Res., 46, 2532 (1986), Sawutz, D., et al.: Biochem. Pharm., 51, 1631 (1996), Voest, E., et al.: Anti-Cancer Drugs, 7, 723 (1996), Connolly, C., et al.: Bioorg. Med. Chem. Lett., 7(18), 2415 (1997), Hamby, J., et al.: J. Med. Chem., 40, 2296 (1997)

物理状态 :
Solid
溶解度 :
Soluble in water, methanol, and DMSO (100 mM).
保存 :
Store at 4° C
熔点 :
236-241° C
折射率 :
n20D ~1.64 (Predicted)
IC50 :
c-Src: IC50 = 8.4 nM; Wee 1: IC50 = 24 nM; Flg: IC50 = 39.3 nM; MYT1: IC50 = 72 nM; EGFR: IC50 = 87.5 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
9916391
MDL 号码 :
MFCD18086890
SMILES :
CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl

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PMID: # 24229357  Rohe, A. et al. 2014. Assay Drug Dev Technol. 12: 136-44.

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