Date published: 2025-9-9

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Pax-3 抗体 (A-5): sc-376215

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说明书
  • Pax-3抗体(A-5)是小鼠单克隆IgG1 κ, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Pax-3的C-terminus附近的氨基酸387-425之间
  • 推荐用于 mouse, rat, human 和 来源的Pax-3 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, bovine, porcine and avian
  • 可用于ChIP的TransCruz试剂(sc-376215 X, 200 µg/0.1 ml)
  • 看 Pax-3/7 (B-5): sc-365843,可查看有标记的 Pax-3 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是Pax-3 Antibody (A-5) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Pax-3 Antibody (A-5) 打包提供(请参阅下面的订购信息)。

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関連項目

Pax基因包含与果蝇中参与早期发育编程的基因具有高度同源性的配对结构域。PAX3基因的产物是在早期神经发生过程中表达的DNA结合蛋白。Pax-3是一种同时含有配对结构域和配对型同源结构域的蛋白质。在早期神经发生过程中,Pax-3的表达仅限于发育中的脊髓脑室区的有丝分裂细胞,以及后脑、中脑和间脑的不同区域。在10-12天的胚胎中,Pax-3的表达也见于发育中的脊髓神经节、颅面中胚层和四肢间充质的神经嵴细胞。编码转录因子的MITF和Pax-3基因的突变分别导致Waardenburg综合征II(WSII)和WSI/WSIII。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Pax-3 抗体 (A-5) 参考文献:

  1. 横纹肌肉瘤中的 PAX3-FOXO1 融合基因  |  Linardic, CM. 2008. Cancer Lett. 270: 10-8. PMID: 18457914
  2. 色素沉着的PAX途径:Pax3在黑色素生成、黑色素细胞干细胞维持和疾病中的作用。  |  Kubic, JD., et al. 2008. Pigment Cell Melanoma Res. 21: 627-45. PMID: 18983540
  3. Pax-3,一种在早期神经发生过程中表达的新型小鼠 DNA 结合蛋白。  |  Goulding, MD., et al. 1991. EMBO J. 10: 1135-47. PMID: 2022185
  4. PAX3-FOXO1 建立肌生成超级增强子并赋予 BET 溴域脆弱性  |  Gryder, BE., et al. 2017. Cancer Discov. 7: 884-899. PMID: 28446439
  5. PAX3沉默可通过MET/PI3K信号抑制胃癌的增殖和血管生成。  |  Lv, WL., et al. 2020. Neoplasma. 67: 304-311. PMID: 31847528
  6. OTX2-PAX3信号轴调节第3组髓母细胞瘤细胞的命运。  |  Zagozewski, J., et al. 2020. Nat Commun. 11: 3627. PMID: 32686664
  7. 伴有 PAX3/FOXO1 融合的双型鼻窦肉瘤  |  Tosun, I., et al. 2023. Pol J Pathol. 74: 282-285. PMID: 38477090
  8. TRIB3沉默可促进高风险横纹肌肉瘤中Akt通路和PAX3-FOXO1的下调。  |  Gallo-Oller, G., et al. 2024. Exp Hematol Oncol. 13: 38. PMID: 38581035
  9. 节段中胚层中 Pax-3 的表达标志着成肌细胞规格化的早期阶段。  |  Williams, BA. and Ordahl, CP. 1994. Development. 120: 785-96. PMID: 7600957
  10. 三叉神经胎座中 Pax-3 的能力、规格化和诱导。  |  Baker, CV., et al. 1999. Development. 126: 147-56. PMID: 9834194

订购信息

产品名称产品编号规格价格数量收藏夹

Pax-3 抗体 (A-5)

sc-376215
200 µg/ml
$316.00

Pax-3 (A-5): m-IgG Fc BP-HRP 套装

sc-537980
200 µg Ab; 10 µg BP
$354.00

Pax-3 (A-5): m-IgGκ BP-HRP 套装

sc-535478
200 µg Ab; 40 µg BP
$354.00

Pax-3 (A-5): m-IgG1 BP-HRP 套装

sc-545474
200 µg Ab; 20 µg BP
$354.00

Pax-3 (A-5) 中和勝肽

sc-376215 P
100 µg/0.5 ml
$68.00

Pax-3 抗体 (A-5) X

sc-376215 X
200 µg/0.1 ml
$316.00

抗体可以用于ICC吗?

Asked by: han yu
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

What application is the blocking peptide sc-376215 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from good qualityI used this antibody detect mouse kidney tissue lysates, this antibody is good quality antiody,shows the clear band at 57kda.
Date published: 2017-06-14
Rated 5 out of 5 by from Popular antibody!Great choice for Pax-3 detection! Nice solid bands on Western blots using a 1:200 dilution.
Date published: 2017-01-18
Rated 5 out of 5 by from Good Western blot data of PaxGood Western blot data of Pax-3 expression in non-transfected and mouse Pax-3 transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-09-27
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Pax-3 抗体 (A-5) is rated 5.0 out of 5 by 3.
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