p38 gamma MAPK12 Antibody (G5F3): sc-33690
- p38 gamma MAPK12 Antibody (G5F3) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against recombinant p38 of human origin
- recommended for detection of p38 gamma MAPK12 of human origin by WB and IP; may cross-react with p38α and p38δ
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p38 gamma MAPK12 Antibody (G5F3) for WB applications. These reagents are now offered in bundles with p38 gamma MAPK12 Antibody (G5F3) (see ordering information below).
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p38 gamma MAPK12 Antibody (G5F3) is a mouse monoclonal IgG2a antibody that detects p38 gamma MAPK12 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. p38 gamma MAPK12, a member of the mitogen-activated protein kinase (MAPK) family, plays a crucial role in various cellular processes, including stress responses, inflammation, and cell differentiation. p38 gamma MAPK12 is primarily located in the cytoplasm, where activation occurs in response to environmental stressors and cytokines, transducing signals that regulate gene expression and cellular responses. Proper functioning of p38 gamma MAPK12 is vital for maintaining cellular homeostasis and mediating stress effects, as dysregulation can lead to various diseases, including cancer and inflammatory disorders. p38 gamma MAPK12 interacts with several key proteins, such as MAPK-activated protein kinase 2 (MK2) and heat shock protein 27 (HSP27), which are involved in downstream signaling pathways that further influence cell survival and apoptosis. anti-p38 gamma MAPK12 antibody (G5F3) is an essential tool for researchers studying these critical pathways and their implications in health and disease.
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p38 gamma MAPK12 Antibody (G5F3) References:
- p38γ MAPK is required for inflammation-associated colon tumorigenesis. | Yin, N., et al. 2016. Oncogene. 35: 1039-48. PMID: 25961922
- p38γ is essential for cell cycle progression and liver tumorigenesis. | Tomás-Loba, A., et al. 2019. Nature. 568: 557-560. PMID: 30971822
- Targeting p38γ to inhibit human colorectal cancer cell progression. | Su, C., et al. 2019. Biochem Biophys Res Commun. 517: 172-179. PMID: 31349971
- Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation. | Koh, A., et al. 2020. Cell Metab. 32: 643-653.e4. PMID: 32783890
- The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma. | Yin, DP., et al. 2022. Cell Death Dis. 13: 210. PMID: 35246508
- p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases. | Fajardo, P., et al. 2022. Cancer Commun (Lond). 42: 897-901. PMID: 35796643
- Pan-cancer analysis supports MAPK12 as a potential prognostic and immunotherapeutic target in multiple tumor types, including in THCA. | Wang, J., et al. 2022. Oncol Lett. 24: 445. PMID: 36420075
- p38γ MAPK delays myelination and remyelination and is abundant in multiple sclerosis lesions. | Marziali, LN., et al. 2024. Brain. 147: 1871-1886. PMID: 38128553
- p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia. | Romero-Becerra, R., et al. 2023. Nat Cardiovasc Res. 2: 1204-1220. PMID: 39196141
- CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence. | Cho, Y. and Kim, YK. 2024. Redox Biol. 76: 103344. PMID: 39265499
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p38 gamma MAPK12 Antibody (G5F3) | sc-33690 | 200 µg/ml | $322.00 | |||
p38 gamma MAPK12 Antibody (G5F3): m-IgG Fc BP-HRP Bundle | sc-536778 | 200 µg Ab; 10 µg BP | $361.00 | |||
p38 gamma MAPK12 Antibody (G5F3): m-IgGκ BP-HRP Bundle | sc-533942 | 200 µg Ab; 40 µg BP | $361.00 |