p33ING1 Antibody (CAb 9): sc-21729
- p33ING1 Antibody (CAb 9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant GST-p33ING1 of human origin
- recommended for detection of p33ING1 of human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p33ING1 Antibody (CAb 9) for WB applications. These reagents are now offered in bundles with p33ING1 Antibody (CAb 9) (see ordering information below).
p33ING1 Antibody (CAb 9) is a mouse monoclonal IgG1 antibody that detects p33ING1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p33ING1 plays a crucial role as a tumor suppressor, with its gene frequently exhibiting mutations or reduced expression in various tumor cell lines, particularly in gastric cancers and head and neck squamous carcinomas. p33ING1 is primarily located in the nucleus, where anti-p33ING1 antibody (CAb 9) can detect interactions with tumor suppressor p53, enhancing p53′s ability to induce growth arrest and programmed cell death. This interaction is vital, as p33ING1 not only modulates p53′s transcriptional activity but is also essential for p53-mediated negative regulation of cell proliferation. By promoting these cellular processes, p33ING1 contributes significantly to maintaining cellular homeostasis and preventing tumorigenesis, making p33ING1 (CAb 9) monoclonal antibody an important tool for cancer research and therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p33ING1 Antibody (CAb 9) References:
- Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. | Garkavtsev, I. 1999. Nat Genet. 23: 373. PMID: 10545957
- Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas. | Shinoura, N., et al. 1999. Cancer Res. 59: 5521-8. PMID: 10554029
- Decreased expression of p33ING1 mRNA in lymphoid malignancies. | Ohmori, M., et al. 1999. Am J Hematol. 62: 118-9. PMID: 10577281
- The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. | Cheung, KJ. and Li, G. 2002. Int J Oncol. 20: 1319-22. PMID: 12012016
- p33(ING1) enhances UVB-induced apoptosis in melanoma cells. | Cheung, KJ. and Li, G. 2002. Exp Cell Res. 279: 291-8. PMID: 12243754
- The tumour suppressor p33ING1 does not regulate migration and angiogenesis in melanoma cells. | Cheung, KJ. and Li, G. 2002. Int J Oncol. 21: 1361-5. PMID: 12429989
- Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2. | Tachibana, M., et al. 2004. Int J Oncol. 25: 913-20. PMID: 15375540
- The expression of p33(ING1), p53, and autophagy-related gene Beclin1 in patients with non-small cell lung cancer. | Liu, J., et al. 2011. Tumour Biol. 32: 1113-21. PMID: 21779982
- Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor. | Garkavtsev, I. and Riabowol, K. 1997. Mol Cell Biol. 17: 2014-9. PMID: 9121449
- Specific monoclonal antibody raised against the p33ING1 tumor suppressor. | Garkavtsev, I., et al. 1997. Hybridoma. 16: 537-40. PMID: 9455706
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p33ING1 Antibody (CAb 9) | sc-21729 | 200 µg/ml | $322.00 | |||
p33ING1 Antibody (CAb 9): m-IgG Fc BP-HRP Bundle | sc-536658 | 200 µg Ab; 10 µg BP | $361.00 | |||
p33ING1 Antibody (CAb 9): m-IgGκ BP-HRP Bundle | sc-533817 | 200 µg Ab; 40 µg BP | $361.00 | |||
p33ING1 Antibody (CAb 9): m-IgG1 BP-HRP Bundle | sc-544742 | 200 µg Ab; 20 µg BP | $361.00 |