p-Bcl-2 Antibody (A-11): sc-377554
- p-Bcl-2 Antibody (A-11) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against a short amino acid sequence containing Thr 74 phosphorylated Bcl-2 of human origin
- Anti-p-Bcl-2 Antibody (A-11) is recommended for detection of Thr 74 phosphorylated Bcl-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-p-Bcl-2 Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for p-Bcl-2 Antibody (A-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with p-Bcl-2 Antibody (A-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
p-Bcl-2 Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Thr 74 phosphorylated Bcl-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-Bcl-2 (A-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Bcl-2 plays a critical role in regulating apoptosis, a vital process that ensures proper cellular turnover and tissue homeostasis. Bcl-2 is primarily located in the outer mitochondrial membrane, where Bcl-2 exerts anti-apoptotic effects by preventing cytochrome c release, a key pro-apoptotic factor. By stabilizing the mitochondrial membrane, Bcl-2 effectively inhibits apoptosome activation, thereby blocking the cascade of events leading to programmed cell death. Dysregulation of Bcl-2, often through mutations or aberrant expression, can lead to various cancers by allowing cells to evade normal apoptotic signals that typically trigger cell death in response to stress or damage. anti-Bcl-2 antibody (A-11) specifically targets the phosphorylated form of Bcl-2, making p-Bcl-2 (A-11) monoclonal antibody an invaluable tool for researchers studying apoptosis mechanisms and cancer biology implications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Bcl-2 Antibody (A-11) | sc-377554 | 200 µg/ml | $322.00 | |||
p-Bcl-2 Antibody (A-11): m-IgG Fc BP-HRP Bundle | sc-526113 | 200 µg Ab; 10 µg BP | $361.00 | |||
p-Bcl-2 Antibody (A-11) AC | sc-377554 AC | 500 µg/ml, 25% agarose | $424.00 | |||
p-Bcl-2 Antibody (A-11) HRP | sc-377554 HRP | 200 µg/ml | $322.00 | |||
p-Bcl-2 Antibody (A-11) FITC | sc-377554 FITC | 200 µg/ml | $336.00 | |||
p-Bcl-2 Antibody (A-11) PE | sc-377554 PE | 200 µg/ml | $349.00 | |||
p-Bcl-2 Antibody (A-11) Alexa Fluor® 488 | sc-377554 AF488 | 200 µg/ml | $364.00 | |||
p-Bcl-2 Antibody (A-11) Alexa Fluor® 546 | sc-377554 AF546 | 200 µg/ml | $364.00 | |||
p-Bcl-2 Antibody (A-11) Alexa Fluor® 594 | sc-377554 AF594 | 200 µg/ml | $364.00 | |||
p-Bcl-2 Antibody (A-11) Alexa Fluor® 647 | sc-377554 AF647 | 200 µg/ml | $364.00 | |||
p-Bcl-2 Antibody (A-11) Alexa Fluor® 680 | sc-377554 AF680 | 200 µg/ml | $364.00 | |||
p-Bcl-2 Antibody (A-11) Alexa Fluor® 790 | sc-377554 AF790 | 200 µg/ml | $364.00 | |||
p-Bcl-2 (A-11) Neutralizing Peptide | sc-377554 P | 100 µg/0.5 ml | $69.00 |