Otoconin 90 Antibody (D-2): sc-376855

Otoconin 90 Antibody (D-2) is a mouse monoclonal IgM antibody that detects Otoconin 90 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Otoconin 90 antibody (D-2) is available as the non-conjugated form. Otoconin 90, also known as PLA2L (phospholipase A2 homolog) or OC90, plays a crucial role in forming and regulating otoconia, which are essential for the vestibular system′s ability to sense gravity and linear motion. Located in vestibular macular organs, otoconia are composed of proteins and calcium carbonate crystals, and their inertial mass provides necessary shearing force to stimulate mechanoreceptors in the utricle and saccule, organs responsible for detecting changes in head position. Otoconin 90, a 493 amino acid secreted protein belonging to the phospholipase A2 family, consists of three PA2-type domains and is vital for recruiting other matrix components that contribute to the organic matrix of otoconia. Otoconin 90 is encoded on human chromosome 8, a region associated with various diseases and malignancies, highlighting this protein′s significance not only in sensory function but also in potential pathological conditions.

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Otoconin 90 Antibody (D-2) References:

1. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes.  |  Kowalski, PE., et al. 1999. Genomics. 57: 371-9. PMID: 10329003
2. Development and maintenance of otoconia: biochemical considerations.  |  Thalmann, R., et al. 2001. Ann N Y Acad Sci. 942: 162-78. PMID: 11710459
3. Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice.  |  Ignatova, EG., et al. 2004. Hear Res. 194: 65-72. PMID: 15276677
4. Inactivation of NADPH oxidase organizer 1 results in severe imbalance.  |  Kiss, PJ., et al. 2006. Curr Biol. 16: 208-13. PMID: 16431374
5. Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix.  |  Zhao, X., et al. 2007. Dev Biol. 304: 508-24. PMID: 17300776
6. Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish.  |  Petko, JA., et al. 2008. Dev Neurobiol. 68: 209-22. PMID: 18000829
7. Otoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutants.  |  Zhao, X., et al. 2008. Neuroscience. 153: 289-99. PMID: 18355969
8. Osteopontin is not critical for otoconia formation or balance function.  |  Zhao, X., et al. 2008. J Assoc Res Otolaryngol. 9: 191-201. PMID: 18459000
9. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.  |  Wang, Y., et al. 1998. Proc Natl Acad Sci U S A. 95: 15345-50. PMID: 9860971

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Otoconin 90 Antibody (D-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Otoconin 90 Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Otoconin 90 Antibody (D-2) Specifications

Alternate Product Name: Otoconin 90

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 115-147

Epitope Target: Otoconin 90

Epitope Species: human

Product Reactivity/Detection: Otoconin 90

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Otoconin 90 Antibody (D-2): P: Blocking Peptide