OG-L002 CAS: 1357302-64-7
MF: C15H15NO
OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively..

OG-L002 (CAS 1357302-64-7)

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同义词: 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
应用; OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
CAS号码: 1357302-64-7
分子量: 225.29
分子式: C15H15NO
* 参考分析证明 大量特定数据 (包括水 含量).
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Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 µM). It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes. OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.

物理状态 :
Solid
保存 :
Store at -20° C
沸点 :
~416.7 °C at 760 mmHg (Predicted)
密度 :
~1.2 g/cm3 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
56639570
SMILES :
C1[[email protected]@H]([[email protected]]1N)C2=CC=C(C=C2)C3=CC(=CC=C3)O

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