NNC 55-0396 CAS: 357400-13-6
MF: C30H38FN3O2•2HCl
MW: 564.57
A calcium channel protein inhibitor.

NNC 55-0396 (CAS 357400-13-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
NNC 55-0396 is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
备用名: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
应用; NNC 55-0396 is a calcium channel protein inhibitor
CAS号码: 357400-13-6
分子量: 564.57
分子式: C30H38FN3O22HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

NNC 55-0396 is a nonhydrolyzable analog of Mibefradil dihydrochloride (sc-204083) which functions as a selective T-type calcium channel protein inhibitor. Studies indicate that NNC 55-0396 displays similar potency on T-type Ca2+ currents in HEK 293/α1G as Mibefradil. NNC 55-0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may function by dissolving in or passing through the plasma membrane of cells.


参考文献

1. Huang, L., et al. 2004. J. Pharmacol. Exp.Ther. 309: 193-199.<

物理状态 :
Solid
溶解度 :
Soluble in water (25 mM).
保存 :
Store at room temperature
沸点 :
674.9° C at 760 mmHg (Predicted)
折射率 :
n20D ~1.60 (Predicted)
IC50 :
Cav3.1 T-type channels: IC50 = 6.8 µM (INS-1 cells); HVA currents: IC50 > 100 µM (INS-1 cells)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CC(C)[[email protected]]1C2=C(CC[[email protected]@]1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)C5CC5)C=C(C=C2)F.Cl.Cl

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

NNC 55-0396 (CAS 357400-13-6)  产品相关文献索引

看其他用户如何应用NNC 55-0396 (CAS 357400-13-6).点击进入浏览PubMed条目 .

引用1 - 22

PMID: # 30755443  Visa, A. et al. 2019. Cancer Res.

PMID: # 24316474  2014. Neuroscience. 259: 126-41.

引用1 - 22
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 123ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话(021) 800-820-8626。 版权 ©, 2007-2021圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。