Molecular structure of N-Desmethyl Imatinib, CAS Number: 404844-02-6
N-Desmethyl Imatinib (CAS 404844-02-6)
See product citations (4)
Alternate Names:
N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide; N-Desmethyl Gleevec; Norimatinib
Application:
N-Desmethyl Imatinib is a metabolite of Imatinib
CAS Number:
404844-02-6
Purity:
≥98%
Molecular Weight:
479.58
Molecular Formula:
C28H29N7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Desmethyl Imatinib is a compound that is primarily utilized in research applications for its role as a major metabolite of imatinib, which allows for the exploration of metabolic pathways and the effects of biotransformation on chemical action. In the study of chemical metabolism, N-Desmethyl Imatinib is pivotal for understanding the chemical kinetics and the metabolic fate of imatinib. It is also used in analytical chemistry to develop and validate analytical methods for the quantification of imatinib and its metabolites in biological samples. Studies involving N-Desmethyl Imatinib often focus on its interaction with various enzymes, particularly those belonging to the cytochrome P450 family, which are responsible for its formation. Furthermore, researchers investigate the biochemical activity of N-Desmethyl Imatinib itself, comparing it to its parent compound.
N-Desmethyl Imatinib (CAS 404844-02-6) References
- Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. | Schindler, T., et al. 2000. Science. 289: 1938-42. PMID: 10988075
- Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. | Druker, BJ., et al. 2001. N Engl J Med. 344: 1031-7. PMID: 11287972
- Method development and validation for the simultaneous determination of imatinib mesylate and N-desmethyl imatinib using rapid resolution high performance liquid chromatography coupled with UV-detection. | Tan, KL., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 3583-91. PMID: 22000961
- Determination of imatinib and its active metabolite N-desmethyl imatinib in human plasma by liquid chromatography/tandem mass spectrometry. | Zhang, M., et al. 2012. Anal Bioanal Chem. 404: 2091-6. PMID: 22865010
- Determination of unbound fraction of imatinib and N-desmethyl imatinib, validation of an UPLC-MS/MS assay and ultrafiltration method. | Arellano, C., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 907: 94-100. PMID: 23000741
- Should therapeutic drug monitoring of the unbound fraction of imatinib and its main active metabolite N-desmethyl-imatinib be developed? | Gandia, P., et al. 2013. Cancer Chemother Pharmacol. 71: 531-6. PMID: 23183914
- LC-MS-MS determination of imatinib and N-desmethyl imatinib in human plasma. | Zhang, Y., et al. 2014. J Chromatogr Sci. 52: 344-50. PMID: 23574742
- The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. | Liu, XY., et al. 2013. Biomed Res Int. 2013: 789184. PMID: 24369535
- Pharmacokinetics interaction between imatinib and genistein in rats. | Wang, Z., et al. 2015. Biomed Res Int. 2015: 368976. PMID: 25629045
- Impact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib. | Khan, MS., et al. 2016. Xenobiotica. 46: 278-87. PMID: 26161459
- The impact of azole antifungal drugs on imatinib metabolism in human liver microsomes. | Luo, X., et al. 2019. Xenobiotica. 49: 753-761. PMID: 29770723
- Determination of serum imatinib and its' metabolite in patients chronic myeloid leukemia. | Onmaz, DE., et al. 2019. Clin Chim Acta. 497: 120-124. PMID: 31351054
- The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats. | Darweesh, RS., et al. 2020. BMC Pharmacol Toxicol. 21: 77. PMID: 33198812
- Method development for determination of imatinib and its major metabolite, N-desmethyl imatinib, in biological and environmental samples by SA-SHS-LPME and HPLC. | Rahimi Kakavandi, N., et al. 2021. Biomed Chromatogr. 35: e5088. PMID: 33590534
- A Study to Explore the Role of IDH1 (R132) Mutation on Imatinib Toxicity and Effect of ABCG2/OCT1 Expression on N-Desmethyl Imatinib Plasma Level in Egyptian Chronic Myeloid Leukemia Patients. | Sabri, A., et al. 2023. Drug Res (Stuttg). 73: 146-155. PMID: 36630991
Inhibitor of:
Arg, Bcr, c-Abl, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Desmethyl Imatinib, 500 µg | sc-208027 | 500 µg | $398.00 |