N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) CAS: 139332-94-8
MF: C25H41NO3S
MW: 435.7
A methyltransferase substrate.

N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) (CAS 139332-94-8)

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应用; A methyltransferase substrate
CAS号码: 139332-94-8
纯度: ≥98%
分子量: 435.7
分子式: C25H41NO3S
* 参考分析证明 大量特定数据 (包括水 含量).
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N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) is a substrate for the carboxyl methyltransferase that is shown to inhibit Ras carboxyl methylation. The Ras subfamily is usually responsible for cell proliferation and inhibition of it will cause a halt in cell division. This compound has been noted to also be a competitive inhibitor for prenylcysteine methyl transferase which doubles the rate of basal and stimulates insulin secretion in a reversible and ATP-dependent manner. Additionally, this agent has been found to inhibit Integrin β2-induced actin polymerization in neutrophils.


参考文献

1. Volker, C., et al. 1991. FEBS Lett. 295: 189-194. PMID: 1765152
2. Philips, M.R., et al. 1993. Science. 259: 977-980. PMID: 8438158
3. Regazzi, R., et al. 1995. Biochim. Biophys. Acta. 1268: 269-278. PMID: 7548225

外观 :
Viscous oil
物理状态 :
Liquid
溶解度 :
Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml), ethyl acetate, water (11 mg/ml) at 25° C, 0.1M Na2CO3 (11 mg/ml), and DMF (~33 mg/ml).
保存 :
Store at -20° C
折射率 :
n20D 1.52
IC50 :
Signal transduction that are receptor mediated: IC50 = 4 µM (human neutrophils); b2-integrin-induced actin polymerization: IC50 = ~45 nM (neutrophils)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
PubChem CID :
2067
MDL 号码 :
MFCD00216147
EC号码 :
200-578-6
SMILES :
CC(=CCCC(=CCCC(=CCCC(=CCSCC(C(=O)O)NC(=O)C)C)C)C)C

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PMID: # 27710830  Zhao, Y. et al. 2016. Eur. J. Cancer. 68: 38-50.

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