N-Acetyl-S-farnesyl-L-cysteine (AFC) CAS: 135304-07-3
MF: C20H33NO3S
MW: 367.55
An inhibitor of S-farnesylcysteine methyl transferase.

N-Acetyl-S-farnesyl-L-cysteine (AFC) (CAS 135304-07-3)

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同义词: AFC
应用; An inhibitor of S-farnesylcysteine methyl transferase
CAS号码: 135304-07-3
纯度: ≥98%
分子量: 367.55
分子式: C20H33NO3S
* 参考分析证明 大量特定数据 (包括水 含量).
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N-Acetyl-S-farnesyl-L-cysteine is a synthetically derivatized cysteine amino acid inhibitor of S-farnesylcysteine carboxyl methyltransferase enzymes. These enzymes recognize N-Acetyl-S-farnesyl-L-cysteine as a substrate through the farnesyl moiety, and occupation of the binding site blocks processing of farnesylated proteins by the enzyme. Carboxyl methylation of farnesylated proteins is an important modification that regulates protein function. Blockade of methyltransferase processing of platelet rap1 proteins by N-Acetyl-S-farnesyl-L-cysteine leads to inhibition of platelet aggregation. N-Acetyl-S-farnesyl-L-cysteine is also described to block the cellular movement and membrane adhesion of Ras proteins by interfering with carboxyl methylation processing. N-Acetyl-S-farnesyl-L-cysteine as a substrate for isoprenylated protein methyltransferase is described to block fMet-Leu-Phe-stimulated release of superoxide radical anion in neutrophil cells. Inhibition of neutrophil chemotaxis by N-Acetyl-S-farnesyl-L-cysteine also produces suppression of inflammatory response induced by 12-O-tereadecanoyl-phorbol-13-acetate and arachidonic acid.


参考文献

1. Volker, C., et al. 1991. J. Biol. Chem. 266: 21515-21522. PMID: 1939182
2. Huzoor-Akbar, D.A., et al. 1991. J. Biol. Chem. 266: 4387-4391. PMID: 1900293
3. Pérez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 3043-3046. PMID: 1901651
4. Huzoor-Akbar, W., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 868-872. PMID: 8430099
5. Philips, M.R., et al. 1993. Science. 259: 977-980. PMID: 8438158
6. Ding, J., et al. 1994. J. Biol. Chem. 269: 16837-16844. PMID: 8207006
7. Gordon, J.S., et al. 2008. J. Invest. Dermatol. 128: 643-654. PMID: 17882268

外观 :
Oil
物理状态 :
Liquid
溶解度 :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), DMF (~20 mg/ml), 0.1 M Na2CO3 (63 mg/ml), PBS (pH 7.2), and water (63 mg/ml) at 25° C.
保存 :
Store at -20° C
密度 :
1.04 g/mL
折射率 :
n20D 1.52
Ki 数据 :
S-farnesylcysteine methyl transferase: Ki= 20 µM
pK值 :
pKa: 3.31
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
1994
MDL 号码 :
MFCD00871540
SMILES :
CC(=CCCC(=CCCC(=CCSCC(C(=O)O)NC(=O)C)C)C)C

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