Date published: 2025-9-8

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MULK 抗体 (C-7): sc-398943

4.5(2)
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说明书
  • MULK抗体(C-7)是小鼠单克隆mouse IgG1 κ (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列33-262位于human物种的MULK的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的MULK WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是MULK Antibody (C-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与MULK Antibody (C-7) 打包提供(请参阅下面的订购信息)。

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    関連項目

    MULK(多底物脂质激酶),也称为AGK(酰基甘油激酶),是一种422个氨基酸的蛋白质,定位于线粒体膜,在肌肉、心脏、肾脏和大脑中高度表达。MULK包含一个DAGKc结构域,作为脂质激酶,磷酸化单酰基甘油和二酰基甘油,分别形成溶血磷脂酸(LPA)和磷脂酸(PA)。当过量表达时,MULK会增加LPA的产生和分泌,从而转录激活EGFR和ERK信号通路,进而导致细胞生长增加。由于其参与LPA过度生产,MULK与前列腺癌症的发生和发展有关。MULK利用镁作为辅因子,以两种选择性剪接的同工型存在。MULK由位于7q34的基因编码。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    MULK 抗体 (C-7) 参考文献:

    1. 酰甘油激酶在表皮生长因子诱导的前列腺癌细胞有丝分裂过程中的关键作用  |  Spiegel, S. and Milstien, S. 2005. Biochem Soc Trans. 33: 1362-5. PMID: 16246119
    2. 酰甘油激酶:线粒体转运蛋白与脂质生物合成的结合。  |  Mårtensson, CU. and Becker, T. 2017. Trends Cell Biol. 27: 700-702. PMID: 28867158
    3. 甘油酸激酶维持 CD8+ T 细胞的代谢状态和免疫反应  |  Hu, Z., et al. 2019. Cell Metab. 30: 290-302.e5. PMID: 31204281
    4. 甘油酸激酶通过激活PI3K/Akt通路促进β-catenin转位至细胞核,从而促进鼻咽癌细胞的干性。  |  Zhao, Q., et al. 2020. Environ Toxicol. 35: 1299-1307. PMID: 32652857
    5. 甘油酸激酶通过 JAK2/STAT3 通路调节 FOXM1 促进鼻咽癌细胞对紫杉醇的耐药性  |  Zhao, C., et al. 2021. Cytokine. 148: 155595. PMID: 34116927
    6. 肿瘤学中的甘油酸激酶靶向疗法。  |  Chu, B., et al. 2021. Front Cell Dev Biol. 9: 659158. PMID: 34368119
    7. 通过调节 LPAR1/TGF-β/Notch 信号通路,下调酰甘油激酶可抑制高血糖诱导的人视网膜微血管内皮细胞内皮-间充质转化。  |  Wang, H., et al. 2022. Can J Physiol Pharmacol. 100: 142-150. PMID: 34559978
    8. 通过上调FOXO1介导的BCL-2表达,抑制酰甘油激酶可使DLBCL对venetoclax敏感。  |  Ning, N., et al. 2022. Theranostics. 12: 5537-5550. PMID: 35910796
    9. 酰甘油激酶通过与核糖体蛋白 L39 相互作用,促进卵巢癌的进展并调节线粒体的功能。  |  Sun, F., et al. 2022. J Exp Clin Cancer Res. 41: 238. PMID: 35934718
    10. ChatGPT 在放射学委员会式考试中的表现:洞察当前的优势和局限。  |  Bhayana, R., et al. 2023. Radiology. 307: e230582. PMID: 37191485

    订购信息

    产品名称产品编号规格价格数量收藏夹

    MULK 抗体 (C-7)

    sc-398943
    200 µg/ml
    $316.00

    MULK (C-7): m-IgG Fc BP-HRP 套装

    sc-538548
    200 µg Ab; 10 µg BP
    $354.00

    MULK (C-7): m-IgGκ BP-HRP 套装

    sc-536184
    200 µg Ab; 40 µg BP
    $354.00

    MULK (C-7): m-IgG1 BP-HRP 套装

    sc-545759
    200 µg Ab; 20 µg BP
    $354.00

    I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with MULK (C-7): sc-398943?

    Asked by: Professor Griffin
    We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 4 out of 5 by from Nice westernI try the sample antibody, works very well for detect MULK in western blot.
    Date published: 2017-09-21
    Rated 5 out of 5 by from Nice Western blot data of MULK expression in nonNice Western blot data of MULK expression in non-transfected 293T, human MULK transfected 293T MOLT-4, PC-3 and HL-60 whole cell lysates. -SCBT QC
    Date published: 2013-04-08
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    MULK 抗体 (C-7) is rated 4.5 out of 5 by 2.
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