mrnp41 Antibody (A-9): sc-393624

mrnp41 Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects mrnp41 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). mrnp41, also known as Rae1 protein homolog and mRNA export factor, is a 368 amino acid protein that plays a crucial role in the nucleocytoplasmic transport of mRNA, primarily localizing to the nuclear pore complex within the nuclear envelope. This localization facilitates the export of mRNA from the nucleus to the cytoplasm, a vital process for gene expression regulation. Mutations in mrnp41 can lead to the accumulation of poly(A)-containing mRNA in the nucleus, underscoring mrnp41′s essential function as a primary nuclear exporter of mRNA. Additionally, mrnp41 interacts with Nup98 to regulate E-cadherin, an important component of the anaphase-promoting complex, which helps prevent securin degradation, suggesting a potential role in maintaining euploidy. During mitosis, mrnp41 is required alongside NuMA for bipolar spindle formation, highlighting mrnp41′s importance in cell division. With diverse roles in mRNA transport and cell cycle regulation, mrnp41 is critical for maintaining cellular homeostasis, making anti-mrnp41 antibody (A-9) an invaluable research tool for studying these processes.

The preferred mrnp41 antibody is mrnp41 Antibody (A-12): sc-374261.