MOBP Antibody (4C2): sc-517016
- MOBP Antibody (4C2) is a mouse monoclonal IgG1 κ MOBP antibody provided at 100 µg/ml
- raised against amino acids 1-81 representing full length MOBP of human origin
- recommended for detection of MOBP of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MOBP Antibody (4C2). This work is in progress.
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MOBP Antibody (4C2) is a mouse monoclonal IgG1 kappa light chain antibody that detects MOBP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MOBP antibody (4C2) is available as the non-conjugated format. The gene encoding MOBP, or myelin-associated oligodendrocytic basic protein, is located on chromosome 3p22.2 and is a crucial component of the central nervous system′s myelin sheath. MOBP plays a significant role in the structural integrity of myelin, which is essential for proper conduction of electrical impulses along nerve fibers. MOBP exists in several splice variants, including MOBP-71, MOBP-81A, MOBP-99, and MOBP-169, which contain exon 8b and are specifically directed to sites of myelin sheath assembly, contributing to myelin formation. In contrast, variants such as MOBP-69, MOBP-81B, and MOBP-170, which lack exon 8b, are retained in the oligodendrocyte soma and may have regulatory functions. MOBP′s importance is underscored by involvement in demyelinating diseases such as multiple sclerosis, highlighting potential as a target for therapeutic intervention.
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MOBP Antibody (4C2) References:
- Evidence that the proposed novel human 'neurokinin-4' receptor is pharmacologically similar to the human neurokinin-3 receptor but is not of human origin. | Sarau, HM., et al. 2000. Mol Pharmacol. 58: 552-9. PMID: 10953048
- Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine. | Renzi, D., et al. 2000. Am J Pathol. 157: 1511-22. PMID: 11073811
- Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction. | Rameshwar, P. and Gascón, P. 1995. Blood. 86: 482-90. PMID: 7541664
- Hematopoietic modulation by the tachykinins. | Rameshwar, P. and Gascón, P. 1997. Acta Haematol. 98: 59-64. PMID: 9286300
- Immunoelectron microscopic localization of NK-3 receptor in the rat spinal cord. | Zerari, F., et al. 1997. Neuroreport. 8: 2661-4. PMID: 9295096
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MOBP Antibody (4C2) | sc-517016 | 100 µg/ml | $322.00 |