MGD sodium salt monohydrate CAS: 91840-27-6
MF: C8H16NO5S2•Na•H2O
MW: 311.34
A useful component for the formation of the MGD2-Fe2+complex.

MGD sodium salt monohydrate (CAS 91840-27-6)

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同义词: N-(Dithiocarbamoyl)-N-methyl-D-glucamine•Na•H20; N-Methyl-D-glucamine dithiocarbamate; N-(D-Glucityl)-N-methyldithiocarbamate sodium salt
应用; A useful component for the formation of the MGD2-Fe2+complex
CAS号码: 91840-27-6
纯度: ≥98%
分子量: 311.34
分子式: C8H16NO5S2•Na•H2O
* 参考分析证明 大量特定数据 (包括水 含量).
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MGD sodium salt monohydrate is a useful component for the formation of the MGD2-Fe2+ complex, which is an excellent nitric oxide (NO) spin-trapping reagent. MGD2-Fe2+ complex is unstable thus, use immediately after being made. An excess of MGD to Fe2+ is used for making the complex with FeSO4 to create a more stable complex solution. Acidic conditions should be avoided because dithiocarbamate tends to decompose forming toxic carbon disulfide.


参考文献

Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication: L.A. Shinobu, et al.; Acta Pharmacol. Toxicol. 54, 189 (1984) In vivo spin trapping of nitric oxide in mice: A. Komarov, et al.; BBRC 195, 1191 (1993) Spin trapping of nitric oxide produced in vivo in septic-shock mice: C.-S. Lei & A.M. Komarov; FEBS Lett. 345, 120 (1994) Spin trapping isotopically-labelled nitric oxide produced from [15N]L- arginine and [17O]dioxygen by activated macrophages using a water soluble Fe(++)-dithiocarbamate spin trap: Y. Kotake, et al.; Free Rad. Res. 23, 287 (1995) Continuous and quantitative monitoring of rate of cellular nitric oxide generation: Y. Kotake; Methods Enzymol. 268, 222 (1996) Continuous monitoring of cellular nitric oxide generation by spin trapping with an iron-dithiocarbamate complex: Y. Kotake, et al.; Biochim. Biophys. Acta 1289, 362 (1996) Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997) Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems: A.F. Vanin, et al.; Biochim. Biophys. Acta 1474, 365 (2000) Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase: A.M. Komarov, et al.; Free Radic. Biol. Med. 28, 793 (2000) Detailed methods for the quantification of nitric oxide in aqueous solutions using either an oxygen monitor or EPR: S. Venkataraman, et al.; Free Radic. Biol. Med. 29, 580 (2000) EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell. Mol. Biol. Lett. 7, 142 (2002) Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate: C. Lu & W.H. Koppenol; Free Radic. Biol. Med. 39, 1581 (2005) Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006)

物理状态 :
Solid
溶解度 :
Soluble in water.
保存 :
Store at 4° C
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
57369922
MDL 号码 :
MFCD01862580
SMILES :

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PMID: # 27112665  Hirsh, DJ. et al. 2016. Free radical biology & medicine. 96: 199-210.

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