Mevastatin (Compactin) CAS: 73573-88-3
MF: C23H34O5
MW: 390.5
An HMGCR (HMG-CoA reductase) inhibitor.

Mevastatin (Compactin) (CAS 73573-88-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 133ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
同义词: Compactin
应用; An HMGCR (HMG-CoA reductase) inhibitor
CAS号码: 73573-88-3
纯度: ≥97%
分子量: 390.5
分子式: C23H34O5
* 参考分析证明 大量特定数据 (包括水 含量).
提交对此产品的评价,获得15个CruzCredits

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin (sc-200850) and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.


参考文献

1. Quesney-Huneeus, V., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 5056-5060. PMID: 291922
2. Quesney-Huneeus, V., et al. 1983. J. Biol. Chem. 258: 378-385. PMID: 6848509
3. Evangelopoulos, M.E., et al. 2009. J. Neurosci. Res. 87: 2138-2144. PMID: 19224573
4. Sugazaki, M., et al. 2010. Connect. Tissue Res. 51: 105-112. PMID: 20109072

物理状态 :
Solid
溶解度 :
Soluble in water (Partly miscible), acetone, DMSO (20 mg/ml), 100% ethanol (25 mg/ml), 1:1 ethanol:PBS(pH7.2) (0.5 mg/ml), and DMF (~5 mg/ml).
保存 :
Store at -20° C
熔点 :
152° C
沸点 :
555.01° C at 760 mmHg (Predicted)
密度 :
1.13 g/cm3 at 20° C
折射率 :
n20D 1.54 (Predicted)
光学活性 :
α22/D +283°, c = 0.48 in acetone
IC50 :
TNF-induced NF-κB activation: IC50 = ~17 µM (human myeloid leukemia cells); HMG-CoA reductase: IC50 = 10 nM (rat); HMG-CoA reductase: IC50 = 23 nM (human)
Ki 数据 :
HMG-CoA reductase: Ki(for acid form) = 1 nM (human)
pK值 :
pKa: 13.49
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
EK7907100
PubChem CID :
64715
默克索引 :
14: 6164
MDL 号码 :
MFCD05662341
Beilstein 注册 :
1269441

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

Mevastatin (Compactin)  产品相关文献索引

看其他用户如何应用Mevastatin (Compactin).点击进入浏览PubMed条目 .

引用1 - 1014

PMID: # 26344763  Gabitova, L. et al. 2015. Cell Rep. 12: 1927-38.

PMID: # 26608317  Cuesta-Geijo, MÁ. et al. 2015. J. Virol. 90: 1534-43.

PMID: # 24954548  Harrison, AT. et al. 2015. Chem Biol Drug Des. 85: 290-5.

PMID: # 25188024  Bozza, WP. et al. 2014. PLoS ONE. 9: e107010.

PMID: # 19903814  Vukelic, S. et al. 2010. J. Biol. Chem. 285: 1980-1988.

PMID: # 17485462  Ko, MH. et al. 2007. J. Biol. Chem. 282: 19742-19752.

PMID: # 16407252  Senga, T. et al. 2006. J. Biol. Chem. 281: 6246-6252.

PMID: # 16428899  Crespo, MJ. et al. 2006. Pharmacology. 76: 141-147.

PMID: # 16043642  Sen-Banerjee, S. et al. 2005. Circulation. 112: 720-726.

PMID: # 12952856  Zager, RA. et al. 2003. Am. J. Physiol. Renal Physiol. 285: F1092-F1099.

引用1 - 1014
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 126ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 32ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话1-800-457-3801。 版权 ©, 2007-2020圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。