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MEK-3 Antibody (B-5) - Immunohistochemistry - Image 161012
MEK-3 抗体 (B-5): sc-271779. 福尔马林固定, 石蜡包埋的人乳腺组织的免疫过氧化物酶染色, 显示腺细胞的胞浆染色.
MEK-3 Antibody (B-5) - Immunohistochemistry - Image 161012
MEK-3 抗体 (B-5): sc-271779. 福尔马林固定, 石蜡包埋的人乳腺组织的免疫过氧化物酶染色, 显示腺细胞的胞浆染色.
MEK-3 Antibody (B-5) - Western Blotting - Image 136495
MEK-3 抗体 (B-5): sc-271779. 未转染: sc-110760 (A) 和转染人 MEK-3: sc-158720 (B) 293 全细胞裂解液中 MEK-3 表达的 Western 印迹分析.
MEK-3 抗体 (B-5): sc-271779. 福尔马林固定, 石蜡包埋的人乳腺组织的免疫过氧化物酶染色, 显示腺细胞的胞浆染色.

MEK-3 抗体 (B-5): sc-271779

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说明书
  • MEK-3 抗体 B-5 是小鼠单克隆 IgG3 κ，MEK-3抗体, 在3篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的MEK-3的N-terminus的氨基酸32-61之间
  • 推荐用于 mouse, rat 和 human 来源的MEK-3 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取MEK-3 (B-5): sc-271779的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP 是MEK-3 抗体 (B-5) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与MEK-3 抗体 (B-5) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 MEK 抗体包括 MEK-1, MEK-2, MEK-3, MEK-4, MEK-5, MEK-6 和 MEK-7

MEK-3抗体（B-5）是一种IgG3 κ小鼠单克隆MEK-3抗体（也称为MEK3抗体或SKK2抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的MEK-3蛋白。MEK-3抗体（B-5）可作为非偶联抗MEK-3抗体使用。一个位于MAP激酶上游并负责其激活的蛋白激酶家族已被鉴定。该家族的原型成员，称为MAP激酶激酶或MEK-1，特异性磷酸化ERK的Thr-Glu-Tyr基序中存在的MAP激酶调节苏氨酸和酪氨酸残基。第二个MEK家族成员MEK-2在底物特异性上与MEK-1相似。MEK-3（或MKK-3）的功能是激活p38 MAP激酶，而MEK-4（也称为SEK1或MKK-4）激活p38和JNK MAP激酶。MEK-5似乎特异性磷酸化ERK5，而MEK-6磷酸化p38和p38b。MEK-7（或MKK-7）磷酸化和激活JNK信号转导通路。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MEK-3 抗体 (B-5) 参考文献:

  1. MEK 的主要结构，MEK 是一种蛋白激酶，能使 ERK 基因产物磷酸化。  |  Crews, CM., et al. 1992. Science. 258: 478-80. PMID: 1411546
  2. 以 MKK3 为靶点的新型抗癌策略：分子机制和治疗意义。  |  Baldari, S., et al. 2015. Cell Death Dis. 6: e1621. PMID: 25633290
  3. miR-214 下调 MKK3 并抑制宫颈癌细胞的恶性表型。  |  Peng, R., et al. 2020. Gene. 724: 144146. PMID: 31634561
  4. 辣椒素靶向 MKK3-p38 轴治疗鼻咽癌的潜力  |  Chiang, C., et al. 2020. Theranostics. 10: 7906-7920. PMID: 32685028
  5. 一种新的人类蛋白激酶信号转导途径的组成部分。  |  Zhou, G., et al. 1995. J Biol Chem. 270: 12665-9. PMID: 7759517
  6. 由 MEK 和 MKK 同工酶定义的独立人类 MAP 激酶信号转导途径。  |  Dérijard, B., et al. 1995. Science. 267: 682-5. PMID: 7839144
  7. 一种新的哺乳动物丝裂原活化蛋白激酶激酶 MKK2 的鉴定和表征。  |  Wu, J., et al. 1993. Mol Cell Biol. 13: 4539-48. PMID: 8393135
  8. 新型 MAP 激酶激酶 (MKK6) 的结构和功能特性。  |  Han, J., et al. 1996. J Biol Chem. 271: 2886-91. PMID: 8621675
  9. 一种新的丝裂原活化蛋白激酶（p38beta）的结构和功能特征。  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
  10. 丝裂原活化蛋白激酶激酶 7 是 c-Jun NH2 端激酶的激活剂。  |  Tournier, C., et al. 1997. Proc Natl Acad Sci U S A. 94: 7337-42. PMID: 9207092
  11. MKK7 是一种应激激活的丝裂原活化蛋白激酶激酶，在功能上与半蝶呤有关。  |  Holland, PM., et al. 1997. J Biol Chem. 272: 24994-8. PMID: 9312105
  12. 人 JNKK2（一种新型 Jun NH2-末端激酶特异性激酶）的分子克隆和特征描述。  |  Wu, Z., et al. 1997. Mol Cell Biol. 17: 7407-16. PMID: 9372971

订购信息

产品名称产品编号规格价格数量收藏夹

MEK-3 抗体 (B-5)

sc-271779
200 µg/ml
$316.00

MEK-3 (B-5): m-IgG3 BP-HRP 套装

sc-550562
200 µg Ab; 40 µg BP
$354.00

MEK-3 (B-5) 中和勝肽

sc-271779 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-271779 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-28
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Rated 1 out of 5 by from Reviews misleading- pertain to OLD AbThis antibody has been tested in four cell types, two tissues. They sent us two separate lots. We published over 20 papers with the previous version, made in a different host, and used archived lysates to test this antibody No reactivity to MEK-3 in mice.
Date published: 2019-09-16
Rated 4 out of 5 by from Good for IFThis MEK-3 Antibody (B-5), sc-271779, shows strong specific signal in IF staining in primary rat motor neuron.
Date published: 2018-02-20
Rated 4 out of 5 by from Potent and fairly specific antibodyThis monoclonal antibody was independently tested in-house by Kinexus Bioinformatics Corporation and validated for use for Western blotting. There was strong detection of the ~40 kDa target protein in an A431/HepG2/MCF7 cell lysate mix, but the target was not detected in mouse tissues (brain/testes/thymus/muscle mix). No major cross-reactivities were observed at 2 µg/ml antibody concentration with off-target proteins in the mouse tissues tested. A ~52 kDa medium cross-reactive protein was detectable in the A431/HepG2/MCF7 cell lysate mix.
Date published: 2016-11-10
Rated 5 out of 5 by from Published western blot data using human TPublished western blot data using human T-lymphoma Jurkat cell line. -SCBT Publication Review
Date published: 2015-02-08
Rated 5 out of 5 by from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human breast tissue. -SCBT QC
Date published: 2015-02-05
Rated 5 out of 5 by from Strong band at expected MW in human transfectedStrong band at expected MW in human transfected 293 lysates. -SCBT QC
Date published: 2015-01-16
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MEK-3 抗体 (B-5) is rated 4.0 out of 5 by 6.
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