MEF-2A Antibody (D-6): sc-55500

MEF-2A Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects myocyte enhancer factor-2A (MEF-2A) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MEF-2A plays a crucial role in regulating gene expression during muscle cell, neuronal cell, and T cell differentiation, making MEF-2A essential for proper development and function in these tissues. MEF-2A is primarily located in the nucleus, where MEF-2A acts as a transcription factor by binding to specific DNA sequences in target gene promoter regions. Nuclear localization of MEF-2A enables interaction with other transcriptional regulators, such as co-activators and co-repressors, thereby modulating genes involved in muscle development and function. MEF-2A forms homo- and heterodimers with other MEF-2 family members to enhance regulatory capacity, allowing fine-tuned responses to developmental cues. Differential expression of MEF-2A during embryogenesis highlights MEF-2A′s importance in muscle differentiation and overall development, making anti-MEF-2A antibody (D-6) an invaluable tool for researchers studying muscle biology and related fields.

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MEF-2A Antibody (D-6) References:

1. Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle.  |  McGee, SL. and Hargreaves, M. 2004. Diabetes. 53: 1208-14. PMID: 15111488
2. Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival.  |  Heidenreich, KA. and Linseman, DA. 2004. Mol Neurobiol. 29: 155-66. PMID: 15126683
3. Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.  |  Konno, T., et al. 2010. Proc Natl Acad Sci U S A. 107: 18097-102. PMID: 20923879
4. Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway.  |  Ye, J., et al. 2012. J Mol Cell Cardiol. 53: 578-87. PMID: 22850285
5. Interactions between mitochondria and the transcription factor myocyte enhancer factor 2 (MEF2) regulate neuronal structural and functional plasticity and metaplasticity.  |  Brusco, J. and Haas, K. 2015. J Physiol. 593: 3471-81. PMID: 25581818
6. Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A).  |  Meyer, M., et al. 2018. Mol Cell Endocrinol. 477: 156-162. PMID: 29928931
7. Decreased Myocyte Enhancer Factor 2 Levels in the Hippocampus of Huntington's Disease Mice Are Related to Cognitive Dysfunction.  |  Vidal-Sancho, L., et al. 2020. Mol Neurobiol. 57: 4549-4562. PMID: 32757160
8. MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program.  |  Lu, YW., et al. 2021. Arterioscler Thromb Vasc Biol. 41: 1105-1123. PMID: 33406884
9. HDAC7 promotes cardiomyocyte proliferation by suppressing Myocyte Enhancer Factor 2.  |  Jang, J., et al. 2024. J Mol Cell Biol.. PMID: 39394661
10. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins.  |  Black, BL. and Olson, EN. 1998. Annu Rev Cell Dev Biol. 14: 167-96. PMID: 9891782

The preferred MEF-2A antibody is MEF-2A Antibody (B-4): sc-17785.