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MCM4 抗体 (C-10): sc-48407

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说明书
  • MCM4抗体(C-10)是小鼠单克隆IgG1 κ, 在7篇文献中引用,规格为200 µg/ml
  • 免疫human来源MCM4位于N-terminus 的1-300氨基酸
  • 推荐用于 mouse, rat 和 human 来源的MCM4 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是MCM4 Antibody (C-10) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与MCM4 Antibody (C-10) 打包提供(请参阅下面的订购信息)。
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MCM4抗体(C-10)是一种小鼠单克隆IgG1抗体,可通过多种应用检测小鼠、大鼠和人类样本中的MCM4,包括蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)。MCM4是微型染色体维持(MCM)蛋白家族的一员,在DNA复制调控中发挥着关键作用,确保每个细胞周期仅复制一次DNA,这对于维持基因组稳定性至关重要。MCM4主要位于细胞核中,与MCM2-7复合物共同构成螺旋酶,在DNA复制开始时发挥作用。这种定位至关重要,因为MCM4与其他复制因子和DNA相互作用,促进复制所需的双链DNA解旋。此外,MCM4的活性受到多种机制的严格调控,包括由细胞周期依赖性激酶(cyclin-dependent kinases)进行的磷酸化,从而确保复制过程与细胞周期精确同步和协调。抗MCM4抗体(C-10)是研究DNA复制动态和细胞分裂复杂调控网络的研究人员的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MCM4 抗体 (C-10) 参考文献:

  1. [MCM4在食管癌中的表达和意义]。  |  Huang, XP., et al. 2007. Ai Zheng. 26: 96-9. PMID: 17222376
  2. 小鼠染色体不稳定的遗传筛选:Mcm4和乳腺癌。  |  Shima, N., et al. 2007. Cell Cycle. 6: 1135-40. PMID: 17495541
  3. 在人类皮肤癌细胞中检测到的MCM4的G364R突变会影响MCM4/6/7复合物的DNA解旋酶活性。  |  Ishimi, Y. and Irie, D. 2015. J Biochem. 157: 561-9. PMID: 25661590
  4. 沉默复制许可因子 MCM4 后,宫颈癌细胞对顺铂的 HPV 型特异性反应。  |  Das, M., et al. 2015. Tumour Biol. 36: 9987-94. PMID: 26188903
  5. Celastrol通过上调DDIT3和ATF3以及下调RRM2和MCM4来调节多种信号通路,从而抑制胰腺癌的增殖。  |  Youns, M., et al. 2021. Onco Targets Ther. 14: 3849-3860. PMID: 34194230
  6. 将 MCM4 鉴定为肝细胞癌的预后标志物  |  Zhou, H., et al. 2021. Biomed Res Int. 2021: 7479326. PMID: 34961841
  7. MCM4是一种新型预后生物标志物,可促进胶质瘤癌细胞的生长。  |  Yang, S., et al. 2022. Front Oncol. 12: 1004324. PMID: 36465369
  8. MCM4的表达与尿路上皮癌的高级别组织学、肿瘤进展和不良预后相关。  |  Kobayashi, G., et al. 2023. Diagn Pathol. 18: 106. PMID: 37737200
  9. MCM4可作为LUAD预后的生物标志物。  |  Tan, Y., et al. 2023. J Cell Mol Med. 27: 3354-3362. PMID: 37817427
  10. MCM4通过Nrf2信号通路增强肝细胞癌对索拉非尼诱导的铁死亡的逃避。  |  Liu, X., et al. 2024. Int Immunopharmacol. 142: 113107. PMID: 39276458

订购信息

产品名称产品编号规格价格数量收藏夹

MCM4 抗体 (C-10)

sc-48407
200 µg/ml
$322.00

MCM4 (C-10): m-IgG Fc BP-HRP 套装

sc-536831
200 µg Ab; 10 µg BP
$361.00

MCM4 (C-10): m-IgGκ BP-HRP 套装

sc-533998
200 µg Ab; 40 µg BP
$361.00

MCM4 (C-10): m-IgG1 BP-HRP 套装

sc-544848
200 µg Ab; 20 µg BP
$361.00

I am using MCM4 (C-10): sc-48407 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: jenniferc
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by ET from Signal via immunoperoxidase staining of formalinSignal via immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of cells in germinal and non-germinal centers. -SCBT QC
Date published: 2015-04-11
Rated 5 out of 5 by JT from Great immunofluorescence nuclear stainingGreat immunofluorescence nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-03-04
Rated 5 out of 5 by LF from Signal via western blot analysis of MCM4Signal via western blot analysis of MCM4 expression in HeLa, NIH/3T3 and KNRK nuclear extracts. -SCBT QC
Date published: 2015-02-18
Rated 5 out of 5 by MS from Publication using Mcm transfected CHO cellsPublication using Mcm transfected CHO cells in CoIP and WB applications -SCBT Publication Review
Date published: 2014-08-07
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MCM4 抗体 (C-10) is rated 5.0 out of 5 by 4.
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