Mastoparan CAS: 72093-21-1
MF: C70H131N19O15
MW: 1478.93
A G-protein activator.

Mastoparan (CAS 72093-21-1)

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应用; A G-protein activator
CAS号码: 72093-21-1
分子量: 1478.93
分子式: C70H131N19O15
* 参考分析证明 大量特定数据 (包括水 含量).
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Mastoparan (Vespula lewisii) has been shown to cause an increase in the production of Arachidonic Acid (sc-200770) catalyzed by PLA2 from porcine pancreas and bee venom. This compound also displays toxicity by regulating G proteins via mimicking of G-protein-coupled receptors. Additionally, Mastoparan has been reported as a stimulator of insulin release by pancreatic islets, which acts through GTP-binding proteins and PLA2. In other experiments, this agent has demonstrated the ability to cause exocytosis of rat peritoneal mast cells and also stimulate the accumulation of inositol phosphates in hepatocytes. Additionally, Mastoparan has been noted to act as a mitogen in Swiss 3T3 cells and stimulate pertussis toxin-sensitive Arachidonate release without phosphoinositide breakdown. Mastoparan (Vespula lewisii) is an inhibitor of CaM. Mastoparan (Vespula lewisii) is an activator of Heterotrimeric G Protein and PLA2.


参考文献

1. Argiolas, A. and Pisano, J.J. 1983. J. Biol. Chem. 258: 13697-13702. PMID: 6643447
2. Higashijima, T., et al. 1988. J. Biol. Chem. 263: 6491-6494. PMID: 3129426
3. Yokokawa, N., et al. 1989. Biochem. Biophys. Res. Commun. 158: 712-716. PMID: 2493246
4. Mousli, M., et al. 1989. J. Pharmacol. Exp. Ther. 250: 329-335. PMID: 2473189
5. Higashijima, T., et al. 1990. J. Biol. Chem. 265: 14176-14186. PMID: 2117607
6. Gil, J., et al. 1991. J. Cell Biol. 113: 943-950. PMID: 1709171

物理状态 :
Solid
来源于 :
Synthetic. Originally isolated from wasp venom (Vespula lewisii)
溶解度 :
Soluble in water (2.6 mg/ml), and 100% ethanol.
保存 :
Store at -20° C
折射率 :
n20D 1.53
IC50 :
Na+,K+-ATPase: IC50 = 7.5 µM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
5464497
MDL 号码 :
MFCD00076865
Beilstein 注册 :
5491949
SMILES :
CC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C(C)CC)C(=O)N[[email protected]@H](CC(C)C)C(=O)N)N

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