Date published: 2025-9-7
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LRP1 抗体 (8G1): sc-57353

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说明书
  • LRP1 抗体 8G1 是小鼠单克隆 IgG1, 在16篇文献中引用，提供 100 µg/ml
  • 针对全长天然LRP1（human起源）的，其细胞外表位与LRP1的515 kDa α链对应
  • 推荐用于 mouse, rat 和 human 来源的LRP1 WB, IF, IHC(P) 和 FCM检测
  • 关于如何获取LRP1 (8G1): sc-57353的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 LRP1 抗体 (8G1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与LRP1 抗体 (8G1) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 LRP 抗体包括 LRP1, LRP11, LRP3, LRP5 和 LRP6

LRP1抗体（8G1）是一种小鼠单克隆IgG1抗体，用于检测低密度脂蛋白受体相关蛋白1（LRP1），也称为α2-巨球蛋白受体（α2MR）。LRP1是一种多功能内吞受体，主要位于细胞表面，在多种配体的内吞过程中发挥着关键作用，包括α2-巨球蛋白和载脂蛋白E（apoE）。LRP1对于脂质代谢、蛋白酶清除和细胞信号传导等过程至关重要，而这些过程对于维持细胞稳态和功能至关重要。LRP1主要在关键组织（如大脑、肝脏和肺）中表达，这凸显了LRP1在神经健康、代谢调节和呼吸功能方面的重要性。此外，LRP1与阿尔茨海默病的发病机制有关，这使得LRP1成为神经退行性疾病研究的重要靶标。抗LRP1抗体（8G1）是针对全长天然人LRP1产生的，特异性靶向515 kDa α链上的胞外表位。LRP1（8G1）抗体推荐用于多种物种，包括小鼠、大鼠和人类，并且适用于多种应用，如蛋白质印迹（WB）、免疫荧光（IF）、免疫组织化学（IHC）和流式细胞术（FCM）。抗LRP1抗体（8G1）能够可靠地检测LRP1，是研究人员研究LRP1在健康和疾病中的复杂作用不可或缺的工具，有助于对细胞功能和治疗潜力的深入研究。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LRP1 抗体 (8G1) 参考文献:

  1. 低密度脂蛋白受体相关蛋白与阿尔茨海默病有关吗？  |  Lambert, JC., et al. 1999. Neurogenetics. 2: 109-13. PMID: 10369887
  2. 在缺乏 VLDL 受体和 ApoE 受体 2 的基因敲除小鼠中，Reeler/Disabled 类神经元迁移中断。  |  Trommsdorff, M., et al. 1999. Cell. 97: 689-701. PMID: 10380922
  3. 极低密度脂蛋白受体的功能域：配体结合和酸依赖性配体解离机制的分子分析。  |  Mikhailenko, I., et al. 1999. J Cell Sci. 112 (Pt 19): 3269-81. PMID: 10504332
  4. 低密度脂蛋白受体相关蛋白的第二和第四簇富含半胱氨酸的 A 类重复序列具有共同的配体结合特性。  |  Neels, JG., et al. 1999. J Biol Chem. 274: 31305-11. PMID: 10531329
  5. 内细胞受体蛋白 LRP 还通过 N-甲基-D-天冬氨酸受体介导神经元钙信号。  |  Bacskai, BJ., et al. 2000. Proc Natl Acad Sci U S A. 97: 11551-6. PMID: 11016955
  6. 低密度脂蛋白受体相关蛋白通路对淀粉样 beta 蛋白清除率和阿尔茨海默氏症易感性的调节。  |  Kang, DE., et al. 2000. J Clin Invest. 106: 1159-66. PMID: 11067868
  7. RAP 在脂蛋白受体生物生成过程中的作用。  |  Bu, G. and Marzolo, MP. 2000. Trends Cardiovasc Med. 10: 148-55. PMID: 11239794
  8. 艾滋病毒感染中的衰老和载脂蛋白E。  |  Li, YH. and Liu, L. 2014. Lipids Health Dis. 13: 136. PMID: 25148848
  9. 脂肪细胞合成的载脂蛋白E和脂蛋白上的载脂蛋白E调节脂肪细胞甘油三酯含量。  |  Gabrielli, AP., et al. 2023. J Alzheimers Dis. 92: 591-604. PMID: 36776072
  10. 线粒体对载脂蛋白E的生物学有深远影响。  |  Na, H., et al. 2023. Neurobiol Aging. 127: 54-69. PMID: 37060729
  11. 载脂蛋白E在调节神经突起生长中的作用：细胞内载脂蛋白E的潜在作用。  |  Pitas, RE., et al. 1998. Biochem Soc Trans. 26: 257-62. PMID: 9649758
  12. 低密度脂蛋白受体相关蛋白的三个补体型重复序列确定了 RAP, PAI-1 和乳铁蛋白的共同结合位点。  |  Vash, B., et al. 1998. Blood. 92: 3277-85. PMID: 9787164

订购信息

产品名称产品编号规格价格数量收藏夹

LRP1 抗体 (8G1)

sc-57353
100 µg/ml
$316.00

LRP1 (8G1): m-IgG Fc BP-HRP 套装

sc-539055
100 µg Ab; 10 µg BP
$354.00

LRP1 (8G1): m-IgG1 BP-HRP 套装

sc-541232
100 µg Ab; 20 µg BP
$354.00

What region of the LRP-1 alpha chain serves as the epitope that this antibody binds to? We are trying to differentiate between LRP-1 segments IV (closer to the cell membrane) and II (more extracellular).

Asked by: MM22
Thank you for your question. The exact epitope recognized by this monoclonal antibody has not yet been determined. We do know that this antibody recognizes the 515 kDa alpha chain of Low Density LRP/alpha2 MR; therefore the epitope is extracellular.
Answered by: Technical Support
Date published: 2020-05-21

May I know the species reactivity and the isotype control suggested for flow cytometry? Thanks

Asked by: Nivetha
Thank you for your question. LRP1 Antibody (8G1) is a mouse monoclonal IgG1 antibody. We recommend it for detection of LRP1 of mouse, rat and human origin by WB, IF, IHC(P) and FCM. The appropriate isotype control for this antibody is normal mouse IgG1: sc-3877. Feel free to also contact our technical service directly if you have further questions.
Answered by: Technical Support Europe
Date published: 2019-04-12

What's the antigen of this antibody, what motif does it identify? I'd like to know whether it binding with the extracellular segment of LRP1.

Asked by: Aori
Thank you for your question. LRP1 Antibody (8G1) is a mouse monoclonal raised against full length native LRP1 protein of human origin. The antibody specifically recognizes the 515 kDa alpha chain of LRP1, which is mapping within an extracellular domain.
Answered by: Technical Support
Date published: 2025-01-28

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with LRP1 Antibody (8G1): sc-57353?

Asked by: Trav11
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Technical Support 15
Date published: 2017-01-24
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Rated 1 out of 5 by from I did not observe staining of LRP1 in HKE293TI tag the constitutive LRP1 of HEK293T cells (i.e., non transduced) using antibody sc-57353, but I could not observe any tagging by flow cytometry.
Date published: 2021-03-01
Rated 4 out of 5 by from goodAntibody was published for use in IHC. It was good product.
Date published: 2020-12-18
Rated 5 out of 5 by from Popular choice for LRP1This antibody, sc-57353: LRP1 (8G1), is a popular choice for Western blot and IHC(P) applications as indicated in 5 current publications featured on the website.
Date published: 2016-12-28
Rated 5 out of 5 by from Positive IHCP data gathered with human frontalPositive IHCP data gathered with human frontal cortex with subcortical white matter -SCBT Publication Review
Date published: 2015-04-05
Rated 5 out of 5 by from WB and ELISA published data with this antibodyWB and ELISA published data with this antibody using mouse RAW 264.7 cell and brain samples -SCBT Publication Review
Date published: 2015-03-08
Rated 5 out of 5 by from Antibody was published for use in WB on human SKAntibody was published for use in WB on human SK-N-SH cells - SCBT Publication Review
Date published: 2013-05-13
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LRP1 抗体 (8G1) is rated 4.2 out of 5 by 6.
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