Date published: 2025-9-11

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LRP 抗体 (1032): sc-23917

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说明书
  • LRP抗体(1032)是小鼠单克隆IgG1 κ, 在4篇文献中引用,规格为200 µg/ml
  • 针对从human起源的MCF7细胞中纯化的LRP
  • 推荐用于 mouse, rat 和 human 来源的LRP WB, IP 和 IF检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是LRP Antibody (1032) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与LRP Antibody (1032) 打包提供(请参阅下面的订购信息)。

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関連項目

对抗癌药物不敏感的肿瘤细胞通常具有多药耐药(MDR)表型。与这一现象相关的蛋白质是运输相关蛋白质,如P-糖蛋白、多药耐药蛋白1、肺耐药相关蛋白(LRP)和乳腺癌耐药蛋白(BCRP)。被鉴定为主要穹隆蛋白(MVP)的LRP蛋白在各种多药耐药癌细胞系和临床样本中过表达。LRP的启动子不含TATA;含有一个倒置的CCAAT盒和一个位于p53结合基序附近的Sp1位点。LRP有两种选择性剪接变体,它们在5'前导区内彼此不同。长LRP亚型普遍表达,代表许多不同正常组织中总LRP mRNA的几乎恒定部分。LRP是多聚核糖核蛋白复合物的主要成分,具有几个未翻译RNA的拷贝,已显示其可沿基于细胞骨架的细胞轨道运输。总之,LRP蛋白可能通过转运过程介导耐药性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LRP 抗体 (1032) 参考文献:

  1. 人类非小细胞肺癌细胞中主要拱顶蛋白 LRP 的表达:短期接触抗肿瘤药物的激活作用。  |  Berger, W., et al. 2000. Int J Cancer. 88: 293-300. PMID: 11004683
  2. 通过 GFP 标记的主要拱顶蛋白观察拱顶颗粒的运动。  |  Slesina, M., et al. 2006. Cell Tissue Res. 324: 403-10. PMID: 16505994
  3. 拱顶和主要拱顶蛋白:在信号通路调节和免疫中的新作用。  |  Berger, W., et al. 2009. Cell Mol Life Sci. 66: 43-61. PMID: 18759128
  4. 以衰老相关凋亡抵抗中的主要拱顶蛋白为靶标。  |  Ryu, SJ. and Park, SC. 2009. Expert Opin Ther Targets. 13: 479-84. PMID: 19335069
  5. 诱导性主要穹顶蛋白在双链 RNA 或病毒诱导的促炎反应中发挥关键作用。  |  Peng, N., et al. 2016. J Immunol. 196: 2753-66. PMID: 26843330
  6. 主要穹隆蛋白通过抑制 STAT3 信号通路抑制肺癌细胞增殖。  |  Bai, H., et al. 2019. BMC Cancer. 19: 454. PMID: 31092229
  7. 主要拱顶蛋白在细菌 N-酰基高丝氨酸内酯诱导的细胞凋亡信号转导中的免疫调节作用。  |  Rayo, J., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33723037
  8. 通过 LRP-1 途径对分泌蛋白和细胞表面蛋白进行靶细胞溶酶体降解。  |  Loppinet, E., et al. 2023. J Am Chem Soc. 145: 18705-18710. PMID: 37590164
  9. 主要苍穹蛋白/肺抵抗相关蛋白:炎症和急性感染的新型生物标记物  |  Routsias, JG., et al. 2024. Microorganisms. 12: PMID: 39338437
  10. 抗药性相关蛋白 LRP 是人类的主要拱顶蛋白。  |  Scheffer, GL., et al. 1995. Nat Med. 1: 578-82. PMID: 7585126

订购信息

产品名称产品编号规格价格数量收藏夹

LRP 抗体 (1032)

sc-23917
200 µg/ml
$316.00

LRP (1032): m-IgG Fc BP-HRP 套装

sc-536687
200 µg Ab; 10 µg BP
$354.00

LRP (1032): m-IgGκ BP-HRP 套装

sc-533847
200 µg Ab; 40 µg BP
$354.00

LRP (1032): m-IgG1 BP-HRP 套装

sc-544767
200 µg Ab; 20 µg BP
$354.00

What is the recommended fixation method for immunofluorescence staining with LRP (1032): sc-23917 monoclonal antibody?

Asked by: Trav11
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Works well in WesternThis antibody shows good detection of LRP in Western Blot in a variety of cell lines - also good in IF.
Date published: 2017-01-31
Rated 5 out of 5 by from Great antibodyMy senior fellow apprentice bought this antibody 3 months ago. I use this antibody a week ago and the result reaches my expectation.
Date published: 2016-12-29
Rated 5 out of 5 by from CoIP and WB publishable data with human QGYCoIP and WB publishable data with human QGY-7703, QGY-7701, HEK293T, and Hela cells - SCBT Publication Review
Date published: 2015-01-19
Rated 5 out of 5 by from Excellent immunofluorescence cytoplasmicExcellent immunofluorescence cytoplasmic staining in methanol-fixed MCF7 cells. -SCBT QC
Date published: 2013-09-12
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LRP 抗体 (1032) is rated 5.0 out of 5 by 4.
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