LBP-1C Antibody (14): sc-135970

LBP-1C Antibody (14) is a mouse monoclonal IgG1 kappa light chain antibody that detects LBP-1C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-LBP-1C antibody (14) is available as a non-conjugated format. LBP-1C protein, also known as TFCP2 (transcription factor CP2), CP2, LSF, SEF, or TFCP2C, is a crucial 502 amino acid nuclear protein belonging to the grh/CP2 family, which plays a significant role in gene regulation. LBP-1C protein is expressed ubiquitously, with highest levels found in the spleen, brain, ovary, kidney, liver, thymus, heart, and lung. LBP-1C protein is essential for transcriptional activation as LBP-1C protein binds to promoters of several key genes, including those encoding fibrinogen, hemoglobin α, and viral HIV-1 protein. LBP-1C protein functions as part of the stage selector protein (SSP) complex, where LBP-1C protein forms dimers to bind DNA, facilitating interaction between enhancer elements and target promoters, thereby enhancing transcriptional activity. Defects in the gene encoding LBP-1C have been linked to various neurodegenerative conditions, including Alzheimer′s Disease, depression, and Purkinje cell degeneration. LBP-1C protein is expressed in two isoforms due to alternative splicing, which may contribute to diverse regulatory functions in cellular processes.

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LBP-1C Antibody (14) References:

1. Purification and characterization of the serum amyloid A3 enhancer factor.  |  Bing, Z., et al. 1999. J Biol Chem. 274: 24649-56. PMID: 10455131
2. Inhibition of the mammalian transcription factor LSF induces S-phase-dependent apoptosis by downregulating thymidylate synthase expression.  |  Powell, CM., et al. 2000. EMBO J. 19: 4665-75. PMID: 10970859
3. The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.  |  Lambert, JC., et al. 2000. Hum Mol Genet. 9: 2275-80. PMID: 11001930
4. Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease.  |  Taylor, AE., et al. 2001. J Med Genet. 38: 232-3. PMID: 11283204
5. Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families.  |  Bertram, L., et al. 2005. J Med Genet. 42: 857-62. PMID: 16272261
6. Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters.  |  Bosè, F., et al. 2006. Mol Cell Biol. 26: 3942-54. PMID: 16648487
7. Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression.  |  Schahab, S., et al. 2006. Dement Geriatr Cogn Disord. 22: 95-8. PMID: 16710089
8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.  |  Lim, J., et al. 2006. Cell. 125: 801-14. PMID: 16713569
9. Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease.  |  Banerjee, D. and Nandagopal, K. 2007. Cell Mol Neurobiol. 27: 1117-26. PMID: 17902044
10. TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression.  |  Porta-de-la-Riva, M., et al. 2011. Biochem J. 435: 563-8. PMID: 21361876
11. Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2.  |  Swendeman, SL., et al. 1994. J Biol Chem. 269: 11663-71. PMID: 8157699
12. The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene.  |  Cunningham, JM., et al. 1995. Genomics. 30: 398-9. PMID: 8586452