Latanoprost (free acid) CAS: 41639-83-2
MF: C23H34O5
MW: 390.5
An F-series prostaglandin (PG) analog.

Latanoprost (free acid) (CAS 41639-83-2)

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应用; Latanoprost (free acid) is an F-series prostaglandin (PG) analog
CAS号码: 41639-83-2
纯度: ≥98%
分子量: 390.5
分子式: C23H34O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Latanoprost (free acid) is a metabolite of Latanoprost, an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. Therefore making Latanoprost (free acid) is an activator of PGF2αR.


参考文献

1 Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992). 2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000). 3 Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996). 4 Sugamoto, K., Matsushita, Y., Matsui, T. Facile and general method for preparation of (E)-4-hydroxy-2-alkenals. Lipids 32 903-905 (1997).

规划 :
A solution in methyl acetate
物理状态 :
Liquid
溶解度 :
Soluble in water (>0.8 mg/ml at 25° C), ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), and methanol.
保存 :
Store at -20° C
沸点 :
57° C
折射率 :
n20D 1.56 (Predicted)
光学活性 :
α20/D +32°, c = 1 in methanol
IC50 :
Felis catus: EC5050 = 0.71 nM
Ki 数据 :
PGT: Ki= 149 nM (human)
pK值 :
pKa: 4.76 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
52195788
MDL 号码 :
MFCD08056084
SMILES :

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