L-Buthionine sulfoximine CAS: 83730-53-4
MF: C8H18N2O3S
MW: 222.30
A glutathione-synthesis inhibitor that activates oxidative stress.

L-Buthionine sulfoximine (CAS 83730-53-4)

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同义词: L-BSO
应用; A glutathione-synthesis inhibitor that activates oxidative stress
CAS号码: 83730-53-4
纯度: ≥97%
分子量: 222.30
分子式: C8H18N2O3S
* 参考分析证明 大量特定数据 (包括水 含量).
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Buthionine-sulfoximine (BSO) is a glutathione-synthesis inhibitor that activates oxidative stress through irreversibly inhibiting γ-GCSc (γ-glutamylcysteine synthetase). Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of BSO. It has been reported that BSO can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis.


参考文献

1. Reliene, R., et al. 2006. Carcinogenesis. 27: 240-244. PMID: 16162646
2. Lewis-Wambi, J.S., et al. 2008. Breast Cancer Res. 10: R104. PMID: 19061505
3. Han, Y.H., et al. 2009. Int. J. Mol. Med. 24: 261-268. PMID: 19578799
4. Savarino, A., et al. 2009. Retrovirology. 6: 52. PMID: 19486542
5. Takahashi, K., et al. 2010. Biol. Pharm. Bull. 33: 556-560. PMID: 20410585

物理状态 :
Solid
溶解度 :
Soluble in water (>25 mg/mL), aqueous acid, and 1N HCl.
保存 :
Store at -20° C
熔点 :
224-226° C
沸点 :
~382.3° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.54
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
EK7713440
PubChem CID :
119565
MDL 号码 :
MFCD00067000
Beilstein 注册 :
2367136
SMILES :
CCCCS(=N)(=O)CC[[email protected]@H](C(=O)O)N

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PMID: # 31273592  Wang, J.|Wu, D.|Zhang, J.|Liu, H.|Wu, J.|Dong, W.| et al. 2019. Dig. Dis. Sci.

PMID: # 29363570  Cao, Y. et al. 2018. Reproduction. 155: 307-319.

PMID: # 30014903  Shen, M. et al. 2018. Redox Biol. 18: 138-157.

PMID: # 27554969  Banerjee, S. et al. 2016. Free Radic. Biol. Med. 99: 296-307.

PMID: # 27374085  Vittorio, O. et al. 2016. Oncotarget.

PMID: # 25567281  Reniere, ML. et al. 2015. Nature. 517: 170-3.

PMID: # 25875358  Fischer, MJ. et al. 2015. PloS one. 10: e0123762.

PMID: # 26446958  Le Gal, K. et al. 2015. Sci Transl Med. 7: 308re8.

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PMID: # 23426973  Maryon, EB. et al. 2013. Am. J. Physiol., Cell Physiol. 304: C768-79.

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