Date published: 2025-9-8

021-6093-6350

SCBT Portrait Logo
Seach Input

karyopherin α2 抗体 (G-11): sc-55537

5.0(7)
寫評論提問

说明书
  • karyopherin α2抗体(G-11)是小鼠单克隆IgG2b κ, 在3篇文献中引用,规格为200 µg/ml
  • 免疫human物种的karyopherin α2的氨基酸480-529
  • 推荐用于 mouse, rat 和 human 来源的karyopherin α2 WB, IP, IF 和 ELISA检测
  • 看 karyopherin α2 (B-9): sc-55538,可查看有标记的 karyopherin α2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是karyopherin α2 Antibody (G-11) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与karyopherin α2 Antibody (G-11) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

karyopherin α2 抗体(G-11)是一种小鼠单克隆 IgG2b 抗体,可通过免疫印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附试验(ELISA)等应用检测小鼠、大鼠和人类样本中的 karyopherin α2。Karyopherin α2通过识别和结合特异性底物在核导入过程中发挥着至关重要的作用,这对于调控基因表达和细胞功能至关重要。Karyopherin α2主要位于细胞质中,在细胞质中,Karyopherin α2与货物蛋白上的各种核定位信号相互作用,促进它们穿过核膜的运输。Karyopherin α2的位置使蛋白质能够高效、有选择性地导入细胞核,从而维持细胞的平衡并对环境信号做出反应。此外,Karyopherin α2还与病毒蛋白形成复合物,如EBNA1(Epstein-Barr virus nuclear antigen 1),突出了Karyopherin α2在正常细胞过程和病毒致病过程中的作用。抗核仁蛋白 α2 抗体 (G-11) 是研究核转运机制及其对健康和疾病影响的研究人员的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

karyopherin α2 抗体 (G-11) 参考文献:

  1. 除了核仁蛋白α2/Rch1外,爱泼斯坦-巴尔病毒核抗原-1还与核转运蛋白核仁蛋白α1/NPI-1结合。  |  Ito, S., et al. 2000. Virology. 266: 110-9. PMID: 10612665
  2. 核仁蛋白α2(KPNA2)在17q23-q24染色体低拷贝重复区内的基因组结构以及罗素-西尔弗综合征患者的突变分析。  |  Dörr, SN., et al. 2001. Hum Genet. 109: 479-86. PMID: 11735022
  3. 核仁蛋白α2的核表达预示着晚期乳腺癌患者的不良生存率,与治疗强度无关。  |  Gluz, O., et al. 2008. Int J Cancer. 123: 1433-8. PMID: 18561322
  4. 核仁蛋白α2的高表达预示着非肌肉浸润性膀胱癌和接受根治性膀胱切除术的浸润性膀胱癌患者的预后不良。  |  Jensen, JB., et al. 2011. Eur Urol. 59: 841-8. PMID: 21330047
  5. 核转运受体核仁蛋白α2在体外促进恶性乳腺癌表型。  |  Noetzel, E., et al. 2012. Oncogene. 31: 2101-14. PMID: 21909132
  6. 应激诱导的细胞凋亡信号调节激酶 1 的核导入是由 karyopherin α2/β1 异二聚体介导的。  |  Sturchler, E., et al. 2013. Biochim Biophys Acta. 1833: 583-92. PMID: 23123190
  7. 原发灶和转移淋巴结中的核仁蛋白α2表达与胃癌预后不良和进展有关。  |  Altan, B., et al. 2013. Carcinogenesis. 34: 2314-21. PMID: 23749771
  8. 核仁蛋白α2的表达上调与成年大鼠脑出血后神经元凋亡有关。  |  Xu, Z., et al. 2016. Cell Mol Neurobiol. 36: 755-65. PMID: 26340948
  9. 核仁蛋白α2和斯塔汀1的高表达与胆管和胆囊上皮细胞在胰腺胆管错位的增殖能力和转化有关。  |  Saito, F., et al. 2016. J Surg Oncol. 114: 462-8. PMID: 27338241
  10. 胆管癌中核仁蛋白α2的过度表达与预后不良和吉西他滨敏感性相关,通过DNA修复蛋白的核内转运实现。  |  Tsukagoshi, M., et al. 2017. Oncotarget. 8: 42159-42172. PMID: 28178675

订购信息

产品名称产品编号规格价格数量收藏夹

karyopherin α2 抗体 (G-11)

sc-55537
200 µg/ml
$316.00

karyopherin α2 (G-11): m-IgG Fc BP-HRP 套装

sc-537066
200 µg Ab; 10 µg BP
$354.00

karyopherin α2 (G-11): m-IgGκ BP-HRP 套装

sc-534252
200 µg Ab; 40 µg BP
$354.00

Which is better using PBST vs TBST in western blotting ?

Asked by: Bie3
Thank you for your question. We recommend using TBS-T for Western blot. If you have any further questions, please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-06-28

What is the recommended fixation method for immunofluorescence staining with karyopherin α2 (G-11): sc-55537 monoclonal antibody?

Asked by: Randy McDonald
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-27
  • y_2025, m_8, d_27, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_55537, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Ottimo funzionamentoIn western blot funziona molto bene, senza aspecifici.
Date published: 2023-11-30
Rated 5 out of 5 by from A good antibody against KPNA2This antibody works well in Western blotting in our experiments using samples from cultured human and monkey cell lines.
Date published: 2020-12-10
Rated 5 out of 5 by from StrongStrong, clean band in Western blot analysis of karyopherin 2 expression in BJAB whole cell lysate. -SCBT QC
Date published: 2015-06-23
Rated 5 out of 5 by from Works great for mouse karyopherin 2 tranfectedWorks great for mouse karyopherin 2 tranfected lysates. -SCBT QC
Date published: 2015-04-26
Rated 5 out of 5 by from Published IP data with human HepDES19 cellsPublished IP data with human HepDES19 cells - SCBT Publication Review
Date published: 2015-04-23
Rated 5 out of 5 by from This antibody works great for western blot;This antibody works great for western blot; clean bands present in the following whole cell lysates: HeLa nuclear extract and A-375, NIH/3T3, RAW 264.7, KNRK and 3611-RF. -SCBT QC
Date published: 2015-01-28
Rated 5 out of 5 by from Great immunofluorescence cytoplasmic stainingGreat immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2014-08-25
  • y_2025, m_8, d_27, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_7
  • loc_zh_CN, sid_55537, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
karyopherin α2 抗体 (G-11) is rated 5.0 out of 5 by 7.
  • y_2025, m_8, d_27, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_7
  • loc_zh_CN, sid_55537, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT