Date published: 2025-9-9

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JCAD 抗体 (F-7): sc-515169

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说明书
  • JCAD 抗体 F-7 是小鼠单克隆 IgG1 κ,JCAD抗体, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1021-1320位于mouse物种的JCAD的C-terminus
  • JCAD 抗体 (F-7) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 JCAD
  • 抗JCAD抗体(F-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取JCAD (F-7): sc-515169免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是JCAD Antibody (F-7) for WB applications. 的首选辅助检测试剂,这些试剂现与JCAD Antibody (F-7) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

JCAD抗体(F-7)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的JCAD蛋白。JCAD (F-7) 抗体有非结合型和多种结合型可供选择,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。JCAD蛋白(又称连接性钙粘蛋白)在细胞粘附中起着至关重要的作用,对于维持细胞连接完整性至关重要,而细胞连接完整性对于组织结构和功能至关重要。JCAD功能的破坏会导致细胞相互作用受损,从而导致各种病理状况,包括癌症转移和发育障碍。JCAD蛋白主要定位于细胞膜,在那里JCAD与其他钙粘蛋白和钙粘蛋白相互作用,形成对建立粘附连接至关重要的复合物。这些连接对于维持组织稳态和调节细胞信号通路非常重要。此外,JCAD基因所在的第10号染色体上还包含其他一些重要基因,包括肿瘤抑制基因PTEN,该基因突变后会导致考登综合征。了解JCAD在细胞粘附中的作用以及与其他蛋白的相互作用,有助于发现细胞粘附异常疾病的潜在治疗靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

JCAD 抗体 (F-7) 参考文献:

  1. Charcot-Marie-Tooth 病的分子细胞生物学。  |  Berger, P., et al. 2002. Neurogenetics. 4: 1-15. PMID: 12030326
  2. 核苷酸切除修复基因 ERCC6 在人类染色体 10q11-q21 上的定位。  |  Troelstra, C., et al. 1992. Genomics. 12: 745-9. PMID: 1349298
  3. 受考登综合征影响的 PTEN 启动子突变患者表现出蛋白质翻译异常。  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
  4. 男性受试者血清尿酸在基线和 1 年随访期间的变化及其缔合作用。  |  Choe, JY., et al. 2008. Clin Rheumatol. 27: 483-9. PMID: 17874170
  5. 德国 cDNA 联盟的全 ORF 克隆资源。  |  Bechtel, S., et al. 2007. BMC Genomics. 8: 399. PMID: 17974005
  6. 首次报道考登综合征卵巢胚胎发育不良瘤,伴有种系PTEN突变和PTEN相关的10q肿瘤杂合性缺失。  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
  7. 通过激酶选择性富集,可对整个细胞周期的激酶组进行定量磷酸化蛋白质组学研究。  |  Daub, H., et al. 2008. Mol Cell. 31: 438-48. PMID: 18691976
  8. PTEN:基因组的新守护者。  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
  9. Lys-N 和胰蛋白酶在一种基于 SCX 的精细方法中覆盖了磷酸蛋白质组的互补部分。  |  Gauci, S., et al. 2009. Anal Chem. 81: 4493-501. PMID: 19413330

订购信息

产品名称产品编号规格价格数量收藏夹

JCAD 抗体 (F-7)

sc-515169
200 µg/ml
$316.00

JCAD (F-7): m-IgG Fc BP-HRP 套装

sc-527995
200 µg Ab; 10 µg BP
$354.00

JCAD (F-7): m-IgG1 BP-HRP 套装

sc-533368
200 µg Ab; 20 µg BP
$354.00

JCAD 抗体 (F-7) AC

sc-515169 AC
500 µg/ml, 25% agarose
$416.00

JCAD 抗体 (F-7) HRP

sc-515169 HRP
200 µg/ml
$316.00

JCAD 抗体 (F-7) FITC

sc-515169 FITC
200 µg/ml
$330.00

JCAD 抗体 (F-7) PE

sc-515169 PE
200 µg/ml
$343.00

JCAD 抗体 (F-7) Alexa Fluor® 488

sc-515169 AF488
200 µg/ml
$357.00

JCAD 抗体 (F-7) Alexa Fluor® 546

sc-515169 AF546
200 µg/ml
$357.00

JCAD 抗体 (F-7) Alexa Fluor® 594

sc-515169 AF594
200 µg/ml
$357.00

JCAD 抗体 (F-7) Alexa Fluor® 647

sc-515169 AF647
200 µg/ml
$357.00

JCAD 抗体 (F-7) Alexa Fluor® 680

sc-515169 AF680
200 µg/ml
$357.00

JCAD 抗体 (F-7) Alexa Fluor® 790

sc-515169 AF790
200 µg/ml
$357.00

请问这是KIAA1462的那个JCAD吗

Asked by: April green
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-08-15

I need to use an antibody to detect the protein in samples of bovine origin. Do you know if sc-515169: KIAA1462 (F-7) mouse monoclonal antibody will work?

Asked by: Randy McDonald
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from JCAD Antibody (F-7): sc-515169We are interested in testing this antibody to detect the expression and distribution of JCAD in different ocular tissues by immnoblot and immunofluorescence analyses. If you provide a small aliquot of this antibody, the data derived from it would be shared with you to use it your advertisement and sale.
Date published: 2024-11-19
Rated 5 out of 5 by from Good for IFAntibody works for immunofluorescense staining cell staining with mouse keratinocytes in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Works wellTest on neuroblastoma cells, works fine though some weak unspecific bands can be seen. The JCAD band is just a little bit above the 130kDa marker.
Date published: 2020-12-18
Rated 5 out of 5 by from KIAA1462 抗体性能很好用于做了免疫组化,实验结果显示目的蛋白显色很清楚!浓度用的500:1,没有试过其它浓度,也许低浓度也可以!
Date published: 2018-01-25
Rated 1 out of 5 by from bad resultI got this free sample one week ago.I detected KIAA1462 in H460,H358 whole cell lyates at 1:500 dilution. The background were so high and got non-specific band.I used this antibody at 1:1000 dilution,but there is no change on highly background.
Date published: 2017-11-03
Rated 5 out of 5 by from Great monoclonal antibodyKIAA1462 Antibody (F-7) showed strong and specific band in various samples
Date published: 2017-02-07
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JCAD 抗体 (F-7) is rated 4.3 out of 5 by 6.
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