Iron Chelator, Dp44mT CAS: 152095-12-0
MF: C14H15N5S
MW: 285.37
A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand.

Iron Chelator, Dp44mT (CAS 152095-12-0)

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应用; A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand
CAS号码: 152095-12-0
纯度: ≥95%
分子量: 285.37
分子式: C14H15N5S
* Refer to Certificate of Analysis for lot specific data (including water content).

Iron Chelator, Dp44mT is a cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Iron Chelator, Dp44mT prevents aggressive growth of M109 lung carcinoma in mice and has been shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.


参考文献

Yuan, J., et al. 2004. Blood 104, 1450.

物理状态 :
Solid
溶解度 :
Soluble in DMSO (5 mg/mL).
保存 :
Store at 4° C
熔点 :
165.90° C (Predicted)
沸点 :
438.37° C at 760 mmHg (Predicted)
密度 :
1.20 g/cm3 (Predicted)
折射率 :
n20D 1.64 (Predicted)
IC50 :
HL-60 : IC50 = 10 nM (human); HCT-116: IC50 = 2 nM (human); antiproliferative properties in SK-N-MC cells: IC50 = ≤ 0.06 µM; antiproliferative properties in SK-Mel-28 cells: IC50 = ≤ 0.06 µM; antiproliferative properties in MCF-7 cells: IC50 = ≤ 0.06 µM; antiproliferative properties in MRC-5: IC50 = > 25 µM
pK值 :
pKa: 10.18 (Predicted), pKb: 1.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
德国水公害等级 :
3
PubChem CID :
10334137
MDL 号码 :
MFCD20527329
SMILES :
CN(C)C(=S)NN=C(C1=CC=CC=N1)C2=CC=CC=N2

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