Date published: 2025-9-6

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Importin-8 抗体 (C-5): sc-398854

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说明书
  • Importin-8 抗体 C-5 是小鼠单克隆 IgG1 κ,Importin-8抗体, 在2篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1-59位于human物种的Importin-8的N-terminus
  • Importin-8 抗体 (C-5) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Importin-8
  • 抗Importin-8抗体(C-5)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Importin-8 (C-5): sc-398854免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Importin-8 Antibody (C-5) for WB applications. 的首选辅助检测试剂,这些试剂现与Importin-8 Antibody (C-5) 打包提供(请参阅下面的订购信息)。

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関連項目

Importin-8抗体(C-5)是一种IgG1κ小鼠单克隆Importin-8抗体(也称为IPO8抗体),它通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的Importin-8蛋白。Importin-8抗体(C-5)既以非偶联抗Importin-8抗体形式提供,也以多种偶联形式的抗Importin-8抗体提供,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Importin复合物由Importin-α和Importin-β蛋白组成,它们协助精氨酸或丝氨酸丰富(SR)的多肽跨越细胞核进行转运。Importin-8,也称为IPO8或RanBP8,是一个包含1037个氨基酸的蛋白,它定位于细胞核和细胞质中,并含有一个Importin N-末端结构域。作为Importin-β家族的多个成员之一,Importin-8是Ran(一种GTP酶)的靶标,并被认为在核蛋白导入中发挥作用,充当适配器样蛋白或自主核转运受体。当作为适配器样蛋白时,Importin-8在核孔复合物(NPC)的核质侧与Ran结合,并启动Importin复合物的解离,这一事件将目标底物释放到细胞核中。Importin-8可以单独存在,也可以与Importin-β家族的另一个成员karyopherin β1形成异二聚体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Importin-8 抗体 (C-5) 参考文献:

  1. 信号识别颗粒蛋白 19 通过导入蛋白 8(RanBP8)和转运蛋白导入细胞核。  |  Dean, KA., et al. 2001. J Cell Sci. 114: 3479-85. PMID: 11682607
  2. 分区指导信号识别颗粒的组装。  |  Maity, TS., et al. 2006. Biochemistry. 45: 14955-64. PMID: 17154533
  3. 基因表达定量分析的内源对照验证:在人类慢性醇盐患者大脑皮层中的应用。  |  Johansson, S., et al. 2007. Brain Res. 1132: 20-8. PMID: 17188656
  4. 在 Smads 的核导入中优先利用 Imp7/8。  |  Yao, X., et al. 2008. J Biol Chem. 283: 22867-74. PMID: 18519565
  5. Importin 8是一种基因沉默因子,可将argonaute蛋白靶向不同的mRNA。  |  Weinmann, L., et al. 2009. Cell. 136: 496-507. PMID: 19167051
  6. 导入蛋白 8 可调控成熟 microRNA 向细胞核的运输。  |  Wei, Y., et al. 2014. J Biol Chem. 289: 10270-10275. PMID: 24596094
  7. 导入蛋白8介导真核翻译起始因子eIF4E的m7G帽敏感核导入。  |  Volpon, L., et al. 2016. Proc Natl Acad Sci U S A. 113: 5263-8. PMID: 27114554
  8. Importin-8在小鼠大脑皮层发育过程中调节顶端祖细胞的分裂、树突形成和切向迁移。  |  Nganou, G., et al. 2018. Front Mol Neurosci. 11: 234. PMID: 30042658
  9. Importin 8通过NF-κB途径参与人类牙周炎。  |  Du, Y., et al. 2019. Int J Clin Exp Pathol. 12: 711-716. PMID: 31933878
  10. 运输蛋白:一种新型核蛋白输入途径的核运输受体。  |  Nakielny, S., et al. 1996. Exp Cell Res. 229: 261-6. PMID: 8986607
  11. 一类新型 RanGTP 结合蛋白。  |  Görlich, D., et al. 1997. J Cell Biol. 138: 65-80. PMID: 9214382
  12. 导入素 beta, 运输素, RanBP5 和 RanBP7 在哺乳动物细胞中介导核糖体蛋白的核导入。  |  Jäkel, S. and Görlich, D. 1998. EMBO J. 17: 4491-502. PMID: 9687515

订购信息

产品名称产品编号规格价格数量收藏夹

Importin-8 抗体 (C-5)

sc-398854
200 µg/ml
$316.00

Importin-8 (C-5): m-IgG Fc BP-HRP 套装

sc-527825
200 µg Ab; 10 µg BP
$354.00

Importin-8 (C-5): m-IgG1 BP-HRP 套装

sc-533198
200 µg Ab; 20 µg BP
$354.00

Importin-8 抗体 (C-5) AC

sc-398854 AC
500 µg/ml, 25% agarose
$416.00

Importin-8 抗体 (C-5) HRP

sc-398854 HRP
200 µg/ml
$316.00

Importin-8 抗体 (C-5) FITC

sc-398854 FITC
200 µg/ml
$330.00

Importin-8 抗体 (C-5) PE

sc-398854 PE
200 µg/ml
$343.00

Importin-8 抗体 (C-5) Alexa Fluor® 488

sc-398854 AF488
200 µg/ml
$357.00

Importin-8 抗体 (C-5) Alexa Fluor® 546

sc-398854 AF546
200 µg/ml
$357.00

Importin-8 抗体 (C-5) Alexa Fluor® 594

sc-398854 AF594
200 µg/ml
$357.00

Importin-8 抗体 (C-5) Alexa Fluor® 647

sc-398854 AF647
200 µg/ml
$357.00

Importin-8 抗体 (C-5) Alexa Fluor® 680

sc-398854 AF680
200 µg/ml
$357.00

Importin-8 抗体 (C-5) Alexa Fluor® 790

sc-398854 AF790
200 µg/ml
$357.00

Hi, I am a postdoctoral research fellow in University of Michigan Medical School. I would like to get a quote on this product (sc-398854) for me to place the order in our system. Please let me know if you need more information. Thanks!

Asked by: wtaiting
Thank you for your question. For accurate availability, shipping and pricing information regarding our antibodies, or to receive a quote, please contact Customer Service.
Answered by: Technical Service
Date published: 2024-10-11

I need to use an antibody to detect the protein in samples of bovine origin. Do you know if sc-398854: Importin-8 (C-5) mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Very works with western blottingThis is a very good antibody with western blotting with SAS cells lysate.
Date published: 2020-06-12
Rated 5 out of 5 by from Very good Western blot data of ImportinVery good Western blot data of Importin-8 expression in NTERA-2 cl.D1, HeLa and HEK293 whole cell lysates and HeLa nuclear extract . -SCBT QC
Date published: 2014-02-09
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Importin-8 抗体 (C-5) is rated 5.0 out of 5 by 2.
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