Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The interleukins (ILs) are a broad family of well characterized cytokines, primarily of hematopoietic cell origin. ILs are secreted by immune cells (mainly macrophages, B cells or T cells) that regulate a wide range of immune system functions. The functions of different ILs vary from regulating inflammatory and immune responses, functioning as an autocrine factor and regulating and/or inhibiting other ILs. IL-12 is responsible for the differentiation of naive CD4(+) T cells into type 1 helper T cells that produce interferon-γ (IFN-γ). It also activates production of tumor necrosis factor α (TNFα) from T and natural killer (NK) cells. IL-12 is a heterodimer composed of subunits IL-12A p35 and IL-12B p40. The p40 subunit of IL-12 also combines with p19, a protein that shows no biological activity by itself, to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including activation of the transcription factor Stat4 and IFN-γ production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
could i know what is the difference between using the FUll length Versus the L from IL12B p40 C17.8; sc-57258?
is the L one manufacture for not detect the heterodimer of the il12 protein
Asked by: Shorouk
Thank you for the question. The "L" form on the antibody is just an azide-free form of the antibody, usually used for neutralization studies, sc-57258 L. It is the same antibody as the non L form, so they will both detect the same protein.
Answered by: Tech Service
Date published: 2019-03-20
I bought the L form of this antibody, sc-57258 L for blocking (neutralization). How long can I store this at in the refridgerator?
Asked by: AbPolly
The L form of the antibody should be stored at -20°C. Once thawed, we recommend using as soon as possible, although it is usually stable for up to 2 weeks at 4 degrees.
Rated 5 out of
Versatile Antibody for Mouse SamplesThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and ELISA. Strong, clear signal with little to no background. Beautiful tissue staining.
Date published: 2017-02-08
Rated 3 out of
Nice band seen in WB using mouse recombinant ILNice band seen in WB using mouse recombinant IL-12B p40. -SCBT QC
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