Date published: 2025-9-8

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IGF2BP3 抗体 (DE-7): sc-100766

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说明书
  • IGF2BP3 抗体 DE-7 是小鼠单克隆 IgM,提供 200 µl ascites
  • 免疫human物种的重组IGF2BP3
  • 推荐用于 mouse, rat 和 human 来源的IGF2BP3 WB, IP 和 ELISA检测
  • 目前,我们还没有完成IGF2BP3 抗体 (DE-7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    IGF2BP3抗体(DE-7)是一种IgM小鼠单克隆IGF2BP3抗体,可通过WB、IP和ELISA检测小鼠、大鼠和人源的IGF2BP3。IGF2BP3抗体(DE-7)可作为非偶联抗IGF2BP3抗体形式使用。胰岛素样生长因子2 mRNA结合蛋白(IGF2BPs)结合RNA并影响RNA合成和代谢。IGF2BP1,也称为编码区决定结合蛋白/胰岛素样生长因子II mRNA结合蛋白(CRD-BP)、IMP1或VICKZ1;IGF2BP2 (IMP2、VICKZ2、p62);和IGF2BP2 (IMP3、KOC1、VICKZ3)含有独特的RNA识别基序和四个hnRNP K同源结构域的组合。IGF2BP1在胚胎组织中含量丰富,在81%的结肠癌、73%的肉瘤和58.5%的乳腺癌中表达。它识别c-Myc、IGF-II和t mRNAs以及H19 RNA,并通过IGF-II依赖机制在K-562细胞的增殖中发挥主要作用。IGF2BP2结合IGF-II mRNA的5' UTR并影响肿瘤细胞的生长,其中IGF2BP2与全反式维甲酸诱导的细胞凋亡相关。通过RNA干扰敲低IGF2BP3可降低IGF-II蛋白水平,而不影响IGF-II、c-Myc或β肌动蛋白mRNA和H19 RNA水平。IGF2BP3是胰腺导管上皮癌和高级别发育异常病变的标志物。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    IGF2BP3 抗体 (DE-7) 参考文献:

    1. RBM15通过IGF2BP3依赖性调节TMBIM6的稳定性,从而促进喉鳞状细胞癌的进展。  |  Wang, X., et al. 2021. J Exp Clin Cancer Res. 40: 80. PMID: 33637103
    2. METTL3/IGF2BP3轴通过上调乳腺癌PD-L1 mRNA的N6-甲基腺苷修饰抑制肿瘤免疫监视。  |  Wan, W., et al. 2022. Mol Cancer. 21: 60. PMID: 35197058
    3. IGF2BP3 是抑制肺腺癌细胞铁突变的重要 N6-甲基腺苷生物靶标。  |  Xu, X., et al. 2022. Mater Today Bio. 17: 100503. PMID: 36457846
    4. IGF2BP3驱动的代谢重编程促进非小细胞肺癌对表皮生长因子受体抑制剂的获得性抗性  |  Lin, Z., et al. 2023. Cancer Res. 83: 2187-2207. PMID: 37061993
    5. m6 A通过IGF2BP3/MCM5/Notch轴的依赖性调节促进部分EMT和LUAD转移  |  Yang, X., et al. 2023. Adv Sci (Weinh). 10: e2206744. PMID: 37171793
    6. IGF2BP3 通过与 m6A 修饰相互作用稳定 MMP3 mRNA,从而促进成人心肌再生。  |  Li, S., et al. 2023. Cell Death Discov. 9: 164. PMID: 37188676
    7. 一种由 TGF&beta 激活的环状 RNA;通过增强 IGF2BP3 介导的 PDPN mRNA 稳定性促进肿瘤转移。  |  Li, K., et al. 2023. Nat Commun. 14: 6876. PMID: 37898647
    8. m6A 修饰通过 IGF2BP3 将 mRNA 从多聚体转为 P-体,从而对翻译产生负面调节作用。  |  Shan, T., et al. 2023. Mol Cell. 83: 4494-4508.e6. PMID: 38016476
    9. IGF2BP3 通过上调 SCD 的表达增强宫颈癌的脂质代谢。  |  Han, C., et al. 2024. Cell Death Dis. 15: 138. PMID: 38355626
    10. IGF2BP3 通过内部 m7G 修饰促进 mRNA 降解。  |  Liu, C., et al. 2024. Nat Commun. 15: 7421. PMID: 39198433

    订购信息

    产品名称产品编号规格价格数量收藏夹

    IGF2BP3 抗体 (DE-7)

    sc-100766
    200 µl ascites
    $333.00

    What is the concentration of sc-100766: IMP-3 (DE-7) monoclonal antibody?

    Asked by: TinTin
    Thank you for your question. The concentration of IMP-3 (DE-7): sc-100766 has not been characterized. This antibody is provided as 200 µl of ascites
    Answered by: Technical Support
    Date published: 2017-03-24
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    Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
    Date published: 2015-03-06
    Rated 4 out of 5 by from Nice band seen in WB using KNice band seen in WB using K-562 whole cell lysate. -SCBT QC
    Date published: 2014-05-17
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    IGF2BP3 抗体 (DE-7) is rated 4.0 out of 5 by 2.
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