m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for hnRNP F/H Antibody (1G11) for WB and IHC(P) applications. This reagent is now offered in a bundle with hnRNP F/H Antibody (1G11) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Labware ships FedEx Ground free of charge to the contiguous US
hnRNP F/H Antibody (1G11) is a high quality monoclonal hnRNP F/H antibody (also designated HNRNPF/H1 antibody) suitable for the detection of the hnRNP F/H protein of mouse, rat, human and Xenopus laevis origin. hnRNP F/H Antibody (1G11) is available as both the non-conjugated anti-hnRNP F/H antibody form, as well as multiple conjugated forms of anti-hnRNP F/H antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport, and also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. hnRNP complexes are the major constituents of the spliceosome and in particular, the hnRNP A1 protein is one of the major pre-mRNA/mRNA binding proteins and also one of the most abundant proteins in the nucleus. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. Most hnRNP proteins, including hnRNP C1 and C2, contain one or more RNA binding domains and are implicated in the processing of pre-mRNA. hnRNPs F and H are largely related factors that preferentially associate with poly(rG) regions on RNA. Isoforms of these proteins are often generated by alternative processing of the pre-mRNA and by posttranslational modifications such as phosphorylation on serines and threonines and methylation of arginines.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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