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hnRNP A1/HNRNPA1L2 Antibody (F-8) - Western Blotting - Image 361533
hnRNP A1/HNRNPA1L2 抗体 (F-8): sc-365486. Jurkat (A), MCF7 (B), SW480 (C) 和 KNRK (D) 全细胞裂解液中 hnRNP A1/HNRNPA1L2 表达的 Western 印迹分析.
hnRNP A1/HNRNPA1L2 抗体 (F-8): sc-365486. Jurkat (A), MCF7 (B), SW480 (C) 和 KNRK (D) 全细胞裂解液中 hnRNP A1/HNRNPA1L2 表达的 Western 印迹分析.

hnRNP A1/HNRNPA1L2 抗体 (F-8): sc-365486

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寫評論提問
说明书
  • hnRNP A1/HNRNPA1L2抗体(F-8)是小鼠单克隆IgG1 κ, 在5篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的hnRNP A1的内部区域内的氨基酸231-257之间
  • 推荐用于 hnRNP A1 and HNRNPA1L2 of mouse and human origin and hnRNP A1 of rat origin WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 hnRNP A1 (4B10): sc-32301，可查看有标记的 hnRNP A1/HNRNPA1L2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是hnRNP A1/HNRNPA1L2 Antibody (F-8) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与hnRNP A1/HNRNPA1L2 Antibody (F-8) 搭配使用（请参阅下面的订购信息）。
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関連項目

附加hnRNP抗体，包括hnRNP A, hnRNP A1, hnRNP A2, hnRNP B, hnRNP B1, hnRNP C1, hnRNP C2, hnRNP E1, hnRNP E2, hnRNP F, hnRNP H, hnRNP H3, hnRNP I, hnRNP J, hnRNP K和hnRNP L

异质核核糖核蛋白（hnRNPs）构成一组多肽，这些多肽有助于mRNA转录和前mRNA加工，以及成熟mRNA向细胞质的转运和翻译。它们还与异质核RNA（hnRNA）结合，这是由RNA聚合酶II产生的转录物。目前已知大约有20种hnRNP蛋白，它们的复合物是剪接体的主要组成部分。大多数hnRNP蛋白组分定位于细胞核中；然而有些则在细胞核和细胞质之间穿梭。hnRNPs的A/B亚家族包括A1、A2/B1、A3和A0，在非洲爪蟾中，hnRNP A1、A2和A3在整个发育过程以及成年组织中普遍表达。hnRNP A1和A2/B1通过直接拮抗各种剪接因子的结合以及通过影响前mRNA上的剪接位点选择来调节前mRNA的加工。hnRNP A0基因与其他A/B家族成员不同，它编码一种低丰度蛋白，与mRNA稳定性有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP A1/HNRNPA1L2 抗体 (F-8) 参考文献:

  1. 对hnRNP A1功能与功能障碍在神经退行性疾病发病机理中的作用进行全面分析。  |  Clarke, JP., et al. 2021. Front Mol Biosci. 8: 659610. PMID: 33912591
  2. hnRNP A1/A2在SMN1/2外显子7剪接中的位置依赖效应。  |  Qiu, J., et al. 2022. Biochim Biophys Acta Gene Regul Mech. 1865: 194875. PMID: 36208849
  3. hnRNP A1在RNA代谢调节中并作为潜在的治疗靶点。  |  Feng, J., et al. 2022. Front Pharmacol. 13: 986409. PMID: 36339596
  4. 少突胶质细胞中hnRNP A1功能障碍是多发性硬化症发病机理之一。  |  Jahanbazi Jahan-Abad, A., et al. 2023. Glia. 71: 633-647. PMID: 36382566
  5. 全面了解hnRNP A1在癌症中的作用：与非编码RNA结合的新视角。  |  Siculella, L., et al. 2023. Cancer Gene Ther. 30: 394-403. PMID: 36460805
  6. 在阿尔茨海默氏病模型中，抑制hnRNP A1与HK1 RNA的结合会导致糖酵解功能障碍。  |  Ji, XH., et al. 2023. Front Aging Neurosci. 15: 1218267. PMID: 37744386
  7. microRNA-195-5p/hnRNP A1轴通过调节癌细胞的迁移，促进肝细胞癌的进展。  |  Jung, M., et al. 2023. Biochem Biophys Res Commun. 686: 149183. PMID: 37926044
  8. β-Arrestin2通过促进hnRNP A1介导的PKM2选择性剪接，促进去势抵抗性前列腺癌对多西他赛的耐药性。  |  Zhou, Y., et al. 2023. Discov Oncol. 14: 215. PMID: 38019357
  9. hnRNP A1功能障碍可改变RNA剪接并导致多发性硬化症（MS）中的神经变性。  |  Salapa, HE., et al. 2024. Nat Commun. 15: 356. PMID: 38191621
  10. hnRNP A1、hnRNP A2B1和hnRNP K在tau病中失调，但与tau病理不共定位。  |  Kavanagh, T., et al. 2024. Brain Pathol. e13305. PMID: 39354671

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP A1/HNRNPA1L2 抗体 (F-8)

sc-365486
200 µg/ml
$322.00

hnRNP A1/HNRNPA1L2 (F-8): m-IgG Fc BP-HRP 套装

sc-540344
200 µg Ab; 10 µg BP
$361.00

hnRNP A1 (F-8) 中和勝肽

sc-365486 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-365486 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
  • y_2026, m_10, d_19, h_5CST
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Rated 5 out of 5 by ET from Knockout CRIPSR data using scKnockout CRIPSR data using sc-400704 demonstrated that this excellent monoclonal antibody strongly and specifically detects hnRNP A1. -SCBT QC
Date published: 2015-04-02
Rated 5 out of 5 by JT from Good WB publishable data gathered with mouse brainGood WB publishable data gathered with mouse brain. -SCBT Publication Review
Date published: 2015-03-26
Rated 5 out of 5 by HC from Robust nuclear staining in paraffinRobust nuclear staining in paraffin-embedded human nasopharynx tissue. -SCBT QC
Date published: 2015-03-07
Rated 5 out of 5 by SS from Great monoclonal antibodyGreat monoclonal antibody, works perfect for WB with Jurkat and HeLa nuclear extracts. -SCBT QC
Date published: 2015-01-10
Rated 5 out of 5 by NZ from Worked well for Western in Jurkat whole cellWorked well for Western in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-01-07
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hnRNP A1/HNRNPA1L2抗体 (F-8) is rated 5.0 out of 5 by 5.
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