HLA-DR/DP/DQ/DX Antibody (CR3/43): sc-53302

HLA-DR/DP/DQ/DX Antibody (CR3/43) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect the HLA-DR, HLA-DP, HLA-DQ, and HLA-DX proteins, collectively known as Human Leukocyte Antigen class II molecules. Anti-HLA-DR/DP/DQ/DX antibody (CR3/43) is raised against human tonsil cells, ensuring robust reactivity in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) for human samples. HLA-DR/DP/DQ/DX molecules play a crucial role in the immune system by presenting antigenic peptides to CD4+ T helper cells, thereby orchestrating adaptive immune responses. These class II molecules interact with key proteins such as HLA-DM and HLA-DO, which are essential for peptide loading and exchange within endosomal and lysosomal compartments. Post-translational modifications, particularly glycosylation, are vital for the proper folding, stability, and surface expression of HLA class II proteins, facilitating effective antigen presentation and immune recognition. HLA-DR/DP/DQ/DX monoclonal antibody (CR3/43) is available in both unconjugated form and various conjugated forms including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for diverse experimental needs. Anti-HLA-DR/DP/DQ/DX antibody (CR3/43) supports the advancement of immunological research and the development of therapeutic strategies aimed at manipulating MHC class II pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HLA-DR/DP/DQ/DX Antibody (CR3/43) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-HLA-DR/DP/DQ/DX Antibody (CR3/43) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HLA-DR/DP/DQ/DX Antibody (CR3/43) Specifications

Alternate Product Name: human leukocyte antigen (HLA) DR, DP, DQ, DX

Product Clone Name: CR3/43

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HLA-DR/DP/DQ/DX

Epitope Species: human

Product Reactivity/Detection: HLA-DR/DP/DQ/DX

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for HLA-DR/DP/DQ/DX Antibody (CR3/43): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin