Hinokitiol CAS: 499-44-5
MF: C10H12O2
MW: 164.2
An apoptosis inducer and potent metal chelator.

Hinokitiol (CAS 499-44-5)

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同义词: 4-Isopropyltropolone
应用; An apoptosis inducer and potent metal chelator
CAS号码: 499-44-5
纯度: ≥98%
分子量: 164.2
分子式: C10H12O2
* 参考分析证明 大量特定数据 (包括水 含量).
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Hinokitol, an iron chelator originally extracted from woods of Thuja plicata and Chamaecyparis obtuse, has been found to inhibit ultraviolet B-induced apoptosis in keratinocytes of murine ear skin via antioxidant activity of metallothionein. Additionally, this compound has been found to also cause apoptotic cell death and cell cycle arrest of proliferating F9 cells via iron deprivation, resulting in an arrest at the G1-S interface or S phase. Antimicrobial activity has also been displayed by Hinokitiol through CPA (carboxypeptidase A) inhibition. Other studies have reported Hinokitiol to inhibit melanin synthesis by reducing protein levels of microphthalmia-associated transcription factor (MITF) and of Tyrosinase, a rate limiting melanogenic enzyme. Hinokitiol is an inhibitor of 12-LO.


参考文献

1. Baba, T., et al. 1998. J. Invest. Dermatol.110: 24-28. PMID: 9424082
2. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22: 990-993. PMID: 10513629
3. Tanaka, T., et al. 1999. Cell Biol. Int. 23: 541-550. PMID: 10704238
4. Kim, D.S., et al. 2004. Arch. Pharm. Res. 27: 334-339. PMID: 15089040

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (up to 25 mg/ml), water (up to 25 mg/ml), ethanol, and ether.
保存 :
Store at room temperature
熔点 :
≥ 260° C (lit.)
沸点 :
140° C (lit.) at 10 mmHg
密度 :
1.13 g/cm3
折射率 :
1.553
IC50 :
Tyrosinase: IC50 = 90 nM (Agaricus bisporus ); BRCA1-associated RING domain protein 1: IC50 = 3890 nM (human); FM3A (Breast carcinoma cells): IC50 = 1100 nM (Mus musculus); p53-binding protein Mdm-2: IC50 = 3580 nM (human)
Ki 数据 :
Tyrosinase : Ki= 60 nM (Agaricus bisporus)
pK值 :
pKa: 7.06
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GU4200000
PubChem CID :
3611
默克索引 :
14: 9390
MDL 号码 :
MFCD00040180
EC号码 :
207-880-7
SMILES :
CC(C)C1=CC=CC(=O)C(O)=C1

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