HHV-8 gp64 Antibody (11D1): sc-65444

HHV-8 gp64 Antibody (11D1) is a mouse monoclonal IgG2b kappa light chain antibody that detects HHV-8 gp64 of viral origin by immunofluorescence (IF). Anti-HHV-8 gp64 antibody (11D1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HHV-8, also known as Kaposi′s sarcoma-associated herpesvirus (KSHV), is linked to several serious conditions, including multicentric Castleman′s disease and primary effusion lymphoma, which is a rare form of non-Hodgkin lymphoma that affects body cavities. HHV-8 predominantly infects individuals with compromised immune systems, such as AIDS patients, leading to the development of Kaposi′s sarcoma, a cancer that originates from lymphatic endothelium. HHV-8 gp64 is a glycoprotein located on the surface of the HHV-8 virion envelope, and this structure is crucial for viral infection of host cells. Glycosylation of HHV-8 gp64 is particularly important, as this modification influences viral stability, immune evasion, and interaction with host cell receptors, thereby facilitating effective viral entry and propagation. Understanding HHV-8 gp64′s role in these processes is essential for developing targeted therapies and vaccines against KSHV-related diseases.

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HHV-8 gp64 Antibody (11D1) References:

1. Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells.  |  Zhu, L., et al. 1999. Virology. 256: 381-92. PMID: 10191203
2. Characterization of human herpesvirus-8 K8.1A/B glycoproteins by monoclonal antibodies.  |  Zhu, L., et al. 1999. Virology. 262: 237-49. PMID: 10489357
3. Human herpesvirus 8 glycoprotein K8.1: expression, post-translational modification and localization analyzed by monoclonal antibody.  |  Wu, L., et al. 2000. J Clin Virol. 17: 127-36. PMID: 10942093
4. A prospective seroepidemiological study of human herpesvirus-8 infection and the risk of multiple myeloma.  |  Tedeschi, R., et al. 2001. Br J Cancer. 84: 122-5. PMID: 11139326
5. Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfate.  |  Wang, FZ., et al. 2001. J Virol. 75: 7517-27. PMID: 11462024
6. Kaposi's sarcoma-associated herpesvirus glycoprotein K8.1 is dispensable for virus entry.  |  Luna, RE., et al. 2004. J Virol. 78: 6389-98. PMID: 15163732
7. Human herpesvirus 8: serovprevalence and correlates in tumor patients from Xinjiang, China.  |  He, F., et al. 2007. J Med Virol. 79: 161-6. PMID: 17177299
8. Human herpesvirus-8 ORF K8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts.  |  Chandran, B., et al. 1998. Virology. 249: 140-9. PMID: 9740785

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HHV-8 gp64 Antibody (11D1) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HHV-8 gp64 Antibody (11D1) Specifications

Alternate Product Name: HHV-8 gp64

Product Clone Name: 11D1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: HHV-8 gp64

Epitope Species: HHV-8 gp64

Product Reactivity/Detection: HHV-8 gp64

Species Reactivity/Detection: viral

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for HHV-8 gp64 Antibody (11D1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin